Evidence map›Paper›PMID 40269782›Full record

SynthesisBMC cancer2025

Diagnostic performance of GLIM and PG-SGA for malnutrition assessment in adult cancer patients: a systematic review and meta-analysis.

Jielin Zhou, Shoumei Yang, Ting Liu, Yubei Sun, Suyi Li

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Observational
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jielin Zhou *Department of Oncology, Anhui Provincial Cancer Hospital, the First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui, 230031, China.
Shoumei Yang *Department of Oncology, Anhui Provincial Cancer Hospital, the First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui, 230031, China.
Ting Liu *Department of Pharmaceutics, School of Pharmaceutical Sciences, Anhui Medical College, Hefei, Anhui, 230601, China.
Yubei SunDepartment of Oncology, Anhui Provincial Cancer Hospital, the First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui, 230031, China. sunyubei@gmail.com.
Suyi LiDepartment of Oncology, Anhui Provincial Cancer Hospital, the First Affiliated Hospital, University of Science and Technology of China, Hefei, Anhui, 230031, China. njlisuyi@sina.com.

Funding

National Natural Science Foundation of China 82404241
6 · The paper itself

Abstract

objectiveConsistency between malnutrition defined by Global Leadership Initiative on Malnutrition (GLIM) and Patient-Generated Subjective Global Assessment (PG-SGA) has not been thoroughly elucidated in patients with cancer. The study aimed to compare their consistency, and summarize the impact of malnutrition defined by GLIM on adverse outcomes.

methodPubMed, Embase, Cochrane library and Web of Science databases were searched from inception to May 1, 2024. Initially, the amalgamated sensitivity, specificity and area under curve (AUC) with 95% confidence intervals (CIs) were calculated. Subsequently, hazard ratios (HR) or odd ratios (OR) and 95% CIs for overall survival (OS), all-cause mortality, postoperative complications, disease-free survival (DFS) and recurrence-free survival (RFS) were pooled.

resultFifty-six studies (55,767 participants) were included. Compared with PG-SGA criteria, the overall sensitivity, specificity and area under curve (AUC) for GLIM was 0.71 (95% CI: 0.63-0.78), 0.80 (95% CI: 0.65-0.90) and 0.79 (95% CI: 0.75-0.83). Subgroup analysis revealed that the diagnostic value in Asian or among patients aged under 60 years were higher than non-Asian or those aged over 60 years. Moreover, GLIM-defined malnutrition was significantly associated with overall survival (OS) [hazard ratios (HR) = 1.57, 95% CI: 1.46-1.67], all-cause mortality (HR = 1.43, 95% CI: 1.29-1.57), postoperative complications [odd ratios (OR) = 1.57, 95% CI: 1.40-1.73], disease-free survival (DFS) (OR = 1.52, 95% CI: 1.36-1.68) and recurrence-free survival (RFS) (OR = 1.41, 95% CI: 1.10-1.72).

conclusionGLIM criteria exhibit moderate diagnostic accuracy for identifying malnutrition among patients with cancer, when compared to the PG-SGA. This accuracy is pronounced in the Asian and patients under the age of 60. Furthermore, GLIM-defined malnutrition was significantly associated with OS, DFS, RFS, all-cause mortality and postoperative complication risks in patients with cancer.

Indexed as

MalnutritionNeoplasmsNutrition AssessmentAdultHumansSensitivity and SpecificityCancer-related malnutritionGLIMMeta-analysisPG-SGASystematic review

Identifiers

PMID40269782
PMCPMC12020302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.