Trial reportBMC oral health2025
The clinical efficacy of injectable platelet-rich fibrin (i-PRF) as an adjunct to nonsurgical periodontal therapy in smokers with periodontitis.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06605547 (The Effect of Injectable Platelet-Rich Fibrin As An Adjunct to Non-Surgical Periodontal Therapy on Clinical Parameters in Smokers With Periodontitis), which is not on this map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Injectable Platelet-Rich Fibrin As An Adjunct to Non-Surgical Periodontal Therapy on Clinical Parameters in Smokers With Periodontitis: A Split-Mouth Randomized Controlled Trial
Who cites it
7 citing papers in PubMed.
- Injectable platelet-rich fibrin (iPRF) and postoperative outcomes in mandibular impacted third molar surgery: a split-mouth randomized controlled trial.BMC oral health · 2026Trial
- Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Oral Mesotherapy as an Adjunctive Approach for the Management of Localized Periodontitis: A Case Report.Cureus · 2026Article
- Platelet-derived concentrates in the immunological management of periodontitis: from dysbiosis to personalized approaches.Odontology · 2026Review
- Adjunctive Use of Platelet-Derived Concentrates (Platelet-Rich Plasma, Platelet-Rich Fibrin, Concentrated Growth Factor, Platelet-Poor Plasma) in Non-Surgical Periodontal Therapy: Current Evidence and Comparative Analysis.Journal of clinical medicine · 2026Review
- Comparative evaluation of microneedling-assisted injectable PRP versus PRP for managing thin gingival phenotype: A randomized clinical study.Bioinformation · 2026Article
- Recent Advances in Regenerative Therapies in Periodontology.Dentistry journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmokers with periodontitis generally respond less favorably to nonsurgical treatments compared to nonsmokers. Injectable platelet-rich fibrin (i-PRF) is an effective autogenous material that positively influences various biological processes, including inflammation, wound healing, angiogenesis, and regeneration. This split-mouth randomized controlled study aims to investigate the effects of subgingival i-PRF application on clinical periodontal parameters as an adjunct to scaling and root planning (SRP) in smokers with periodontitis.
methodsThis study included twenty-five patients with Stage 2 to 3 Grade C periodontitis. For each patient, four contralateral deep pockets (two for each side) were randomly treated with SRP + i-PRF (test group) or SRP + saline (control group). Subgingival i-PRF/saline application was repeated on the 7th day, and clinical periodontal parameters were recorded at baseline and 1 and 3 months following the treatments.
resultsCompared with the baseline measurements, both groups presented significant improvements in clinical parameters. The probing depth (PD) was significantly lower in the test group than in the control group at the 1st and 3rd months (P < 0.05). The 3-month gingival index (GI) and bleeding on probing (BOP) values were significantly lower in the test group than in the control group (P < 0.05). No significant differences were observed in the Turesky modified Quigley-Hein Plaque Index (TQHPI) or clinical attachment loss (CAL) score between the groups during the follow-up visits (P > 0.05). However, greater PD reduction and clinical attachment gain were found in the test group than in the control group at the 1st and 3rd months (P < 0.05).
conclusionsGreater PD reduction and clinical attachment gain in the test group indicate that i-PRF may play a beneficial role in improving the clinical outcomes of nonsurgical periodontal treatment in smokers with periodontitis.
trial registrationID NCT06605547 ( https://clinicaltrials.gov/ ); September 23, 2024.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.