Evidence map›Paper›PMID 40269775›Full record

ArticleBMC nephrology2025

Impact of the Geriatric Nutritional Risk Index on short-term prognosis of patients with sepsis-related acute kidney injury: analysis using the MIMIC-IV database.

Kailun Cai, Wenchao Mao, Mingkun Yang, Changqin Chen, Shijin Gong, Lifen Zheng, Changyun Zhao

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In one paragraph

Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kailun Cai *Department of Critical Care Medicine, Zhejiang Hospital, Lingyin Road 12, Hangzhou, Zhejiang, 310013, China.
Wenchao Mao *Department of Critical Care Medicine, Zhejiang Hospital, Lingyin Road 12, Hangzhou, Zhejiang, 310013, China.
Mingkun Yang *Department of Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, China.
Changqin ChenDepartment of Critical Care Medicine, Zhejiang Hospital, Lingyin Road 12, Hangzhou, Zhejiang, 310013, China.
Shijin GongDepartment of Critical Care Medicine, Zhejiang Hospital, Lingyin Road 12, Hangzhou, Zhejiang, 310013, China.
Lifen ZhengChronic Disease Management Center, Quzhou Kecheng People's Hospital, No.172 Shuanggang Road, Quzhou, Zhejiang, 324000, China.
Changyun ZhaoDepartment of Critical Care Medicine, Zhejiang Hospital, Lingyin Road 12, Hangzhou, Zhejiang, 310013, China. zjyyzcy@126.com.

Funding

Guiding Project of Science and Technology Bureau of Kecheng District Quzhou City in 2023: No. 14.
6 · The paper itself

Abstract

backgroundIn critically ill elderly patients, malnutrition is a common comorbidity. The Geriatric Nutritional Risk Index (GNRI) is a straightforward tool for evaluating the nutritional status of elderly individuals. The association between GNRI score and unfavorable health outcomes has been established. However, no studies have yet elucidated the relationship between GNRI score and sepsis-related acute kidney injury (S-AKI).

methodsWe sourced patient data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. All patients were divided into four groups based on their GNRI score using quartile analysis. The main objective of this study was to investigate the 28-day mortality rate. Secondary study outcomes were the incidence of severe AKI, length of stay in the intensive care unit, and days in the hospital. To evaluate the association between GNRI score and study outcomes, we used a Cox proportional hazards regression model and restricted cubic splines. Kaplan-Meier curves were used to compare the outcomes in each group.

resultsA total of 4515 elderly patients with S-AKI were included in this study. Patients were categorized into four groups according to GNRI quartile: Q1 (< 78.92), Q2 (78.92-84.88), Q3 (84.88-90.84), and Q4 (> 90.84). Overall 28-day mortality was 29.5%. Patients with a low GNRI were predominantly women, and had a low body mass index. After controlling for confounding factors, GNRI score emerged as an independent predictor of 28-day mortality among elderly patients with S-AKI (Q4 vs. Q1: hazard ratio 0.74, 95% confidence interval 0.63-0.87; p < 0.001). Restricted cubic spline analysis revealed a linear relationship between GNRI and 28-day mortality (p for non-linearity = 0.207), and this association remained consistent across all subgroup analyses.

conclusionsThe GNRI is an important nutritional assessment tool, and is useful in predicting the prognosis of critically ill elderly patients with S- AKI.

Indexed as

Acute Kidney InjuryGeriatric AssessmentMalnutritionNutritional StatusNutrition AssessmentSepsisAgedAged, 80 and overCritical IllnessDatabases, FactualFemaleHumansIntensive Care UnitsLength of StayMalePrognosisElderlyGeriatric Nutritional Risk IndexSepsisSepsis-related acute kidney injury

Identifiers

PMID40269775
PMCPMC12020311

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.