ArticleBMC geriatrics2025
Associations of the triglyceride-glucose index and triglyceride-glucose/body mass index with all-cause mortality in Chinese centenarians.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of triglyceride-glucose-related composite obesity indices with cardiovascular diseases and mortality: a systematic review and meta-analysis.Cardiovascular diabetology · 2026Pooled it
- Plasma proteomic profiling deciphers molecular dynamics linking insulin resistance to multiple chronic diseases and mortality.Cardiovascular diabetology · 2026Article
- Circulating Adiponectin and Omentin Across Cardiometabolic Phenotypes: Links to Atherogenic Indices in Prediabetes and New-Onset Type 2 Diabetes.International journal of molecular sciences · 2026Article
- Cumulative exposure to the estimated glucose disposal rate and incident stroke in individuals with cardiovascular-kidney-metabolic syndrome stages 0-4: 6-year longitudinal evidence from CHARLS.Cardiovascular diabetology · 2026Article
- The association between cystatin C and hypertension risk in diabetes patients: A multi-cohort cross-sectional study.iScience · 2025Article
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Abstract
backgroundThe triglyceride-glucose (TyG) index and triglyceride-glucose/body mass index (TyG-BMI) have been shown to be associated with cardiovascular and cerebrovascular disorders and the risk of death. The aim of this study was to explore the relationships of the TyG index and TyG-BMI with all-cause mortality among Chinese centenarians.
methodsData from the China Hainan Centenarian Cohort Study (CHCCS) were analyzed. Eligible centenarians were divided into quartiles on the basis of their TyG and TyG-BMI indices. Kaplan‒Meier analysis was used to compare survival times across groups. The associations of the TyG index and TyG-BMI with all-cause mortality were investigated using restricted cubic splines (RCSs) and Cox proportional hazards regression models. Moreover, the concordance of the associations of the TyG index and TyG-BMI with all-cause mortality in different subgroups was further explored by subgroup analysis.
resultsA total of 921 centenarian participants were included in this study. During a median follow-up of 29.70 months, 852 (92.5%) centenarians died. The results of the RCS analysis demonstrated that the TyG index and TyG-BMI were both linearly and negatively associated with all-cause mortality. Compared with that for the highest the TyG index and TyG-BMI quartile groups, higher risks of death were found for the lowest quartile groups (TyG Q1 vs. Q4, HR 1.27, 95% CI 1.03-1.56, P = 0.024; TyG-BMI Q1 vs. Q4, HR 1.60, 95% CI 1.30-1.96, P < 0.001). Centenarians with lower TyG index and TyG-BMI values had significantly greater mortality risks according to the Kaplan‒Meier analysis (log-rank P = 0.020, log-rank P < 0.001, respectively). Subgroup analysis demonstrated that blood pressure could influence the linear negative correlation between the TyG-BMI and all-cause mortality.
conclusionBoth lower TyG and TyG-BMI indices were significantly associated with higher all-cause mortality in Chinese centenarians, whereas the TyG-BMI was superior to the TyG index in predicting the mortality risk of centenarians.
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