Evidence map›Paper›PMID 40269724›Full record

Trial reportBMC gastroenterology2025

A randomized, controlled trial of oral sulfate solution versus polyethylene glycol for bowel preparation for colonoscopy.

Dong-Ling Xie, Jin-Hui Fan, Chan-Juan Fan, Ying-Hui Gao, Jian-Ping Cheng

Abstract readRandomized Controlled TrialComparative StudyEquivalence Trial
In one paragraph

Trial report in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dong-Ling XieDepartment of Gastroenterology and Oncology, Civil Aviation General Hospital, No. 76 Chaoyang Road, Chaoyang District, Beijing, 100123, China.
Jin-Hui FanCivil Aviation Medicine Center, Civil Aviation Administration of China, Beijing, China.
Chan-Juan FanDepartment of Gastroenterology and Oncology, Civil Aviation General Hospital, No. 76 Chaoyang Road, Chaoyang District, Beijing, 100123, China.
Ying-Hui GaoDepartment of Gastroenterology and Oncology, Civil Aviation General Hospital, No. 76 Chaoyang Road, Chaoyang District, Beijing, 100123, China.
Jian-Ping ChengDepartment of Gastroenterology and Oncology, Civil Aviation General Hospital, No. 76 Chaoyang Road, Chaoyang District, Beijing, 100123, China. cjpczy2004@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe quality of colonoscopy is significantly influenced by the effectiveness of bowel preparation. In this study, we aimed to evaluate the efficacy, safety, and tolerability of bowel cleansing between a new oral sulfate solution (OSS) and standard polyethylene glycol electrolyte powder (PEG).

methodsThis single center, randomized, superiority study recruited 679 outpatients who were assigned to either the new OSS group (Group A) or standard PEG group (Group B). The quality of bowel cleansing was evaluated using the Boston Bowel Preparation Scale (BBPS) and compared between the two groups. Furthermore, data pertaining to the duration of bowel preparation, patient tolerability, and the occurrence of adverse events were also analyzed.

resultsAccording to BBPS scores, group A demonstrated significantly higher bowel preparation cleanliness than group B. Additionally, group A achieved superior bowel cleansing, as evidenced by a greater proportion of patients with BBPS scores ≥ 8 compared to group B (75.3% vs. 55.2%, P < 0.05). No severe adverse events were reported during examinations in either group.

conclusionsThe magnesium sulfate, sodium sulfate, and potassium sulfate concentrated oral solution is a novel, safe, and effective bowel preparation for colonoscopy.

trial registrationThis study was registered in the Chinese Clinical Trial Registry on 20/02/2024 (clinical trial registration number: ChiCTR2400081004).

Indexed as

CatharticsColonoscopyMagnesium SulfatePolyethylene GlycolsSulfatesAdministration, OralAdultAgedFemaleHumansMaleMiddle AgedCatharticsMagnesium SulfatePolyethylene Glycolspotassium sulfatesodium sulfateSulfatesBowel PreparationColonoscopyOral sulfate solutionPolyethylene glycolSide effects

Identifiers

PMID40269724
PMCPMC12020202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.