Evidence map›Paper›PMID 40269684›Full record

ArticleBMC cardiovascular disorders2025

Age, inflammation, alkaline phosphatase, and coronary artery calcification in firefighters.

Mingyue Li, Jiali Han, Carolyn Muegge, Terrell Zollinger, Laura Y Zhou, Patrick Monahan, Jennifer Wessel, Vanessa Kleinschmidt, Steven Moffatt, Hongmei Nan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingyue LiDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Jiali HanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Carolyn MueggeNational Institute for Public Safety Health, Indianapolis, IN, USA.
Terrell ZollingerDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Laura Y ZhouDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
Patrick MonahanDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA.
Jennifer WesselDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.
Vanessa KleinschmidtNational Institute for Public Safety Health, Indianapolis, IN, USA.
Steven MoffattNational Institute for Public Safety Health, Indianapolis, IN, USA.
Hongmei NanDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA. hnan@iu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFirefighting involves exposure to hazardous conditions that may contribute to adverse long term health outcomes, including cardiovascular disease. While coronary artery disease (CAD) is a leading cause of morbidity among firefighters, the specific occupational contributions to Coronary Artery Calcification (CAC), a reliable predictor of CAD, are not well understood.

methodsWe conducted a cross-sectional study involving 410 firefighters, aged 35-68, who underwent comprehensive health assessments, including CAC measurement using computed tomography. Multiple logistic regression models were built to examine the associations of demographic, lifestyle, and clinical variables with CAC score.

resultsOur analysis revealed statistically significant associations between several clinical indicators and CAC score. Age (odds ratio (OR): 1.12; 95% confidence interval (95% CI): [1.05, 1.19]) and percentage of monocytes (OR: 1.29; 95% CI: [1.06, 1.58]) were positively correlated with higher CAC score, highlighting the role of inflammation in CAD among firefighters. Moreover, the enzyme alkaline phosphatase emerged as an independent predictor of CAC score (OR: 1.02; 95% CI: [1.01, 1.04]), suggesting a novel biomarker of cardiovascular risk in this population.

conclusionOur study identified several risk factors associated with increased CAC score in firefighters, including age, inflammation, and alkaline phosphatase. These findings underscore the importance of tailored health monitoring and interventions to mitigate CAD risk in firefighters, considering both general and occupation-specific risk factors. This study contributes to a better understanding of the occupational health challenges faced by firefighters and provides a foundation for future research and preventive strategies in this high-risk group.

Indexed as

Alkaline PhosphataseCoronary Artery DiseaseFirefightersInflammationInflammation MediatorsOccupational DiseasesOccupational HealthVascular CalcificationAdultAgedAge FactorsBiomarkersComputed Tomography AngiographyCoronary AngiographyCross-Sectional StudiesFemaleAlkaline PhosphataseBiomarkersInflammation MediatorsAgeAlkaline phosphataseCoronary artery calcificationFirefightersInflammation

Identifiers

PMID40269684
PMCPMC12016472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.