Trial reportNature medicine2025
Cognitive behavioral therapy skills via a smartphone app for subthreshold depression among adults in the community: the RESiLIENT randomized controlled trial.
Trial report in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Smartphone CBT engagement and depressive symptoms: secondary analysis of the RESiLIENT trial using a time-varying exposure approach.Psychological medicine · 2026Trial
- Effects of smartphone cognitive behavioural therapy on social functioning in non-depressive and subthreshold depressive adults: a secondary analysis of the RESiLIENT trial.BMJ mental health · 2026Trial
- Smartphone cognitive behavioral therapy for prevention of depressive symptoms in patients with recurrent pregnancy loss: an exploratory decentralized, parallel-group, multicenter, open, individually randomized, fully factorial trial.Psychiatry and clinical neurosciences · 2026Trial
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Identifying the active ingredients of a behavioral activation-based digital single-session intervention targeting depression.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Building evidence on digital psychotherapies for adults living with depression: a systematic scoping review of populations, interventions and design features of ongoing and planned randomised controlled trials.BMJ mental health · 2026Article
- A clinically actionable framework for personalizing iCBT to improve depression outcomes.NPJ digital medicine · 2026Review
- Article
- Predictors of depression outcomes among university students following brief smartphone-based interventions.Npj mental health research · 2026Article
- Associations between smart health device use and depressive symptoms in older adults from the China longitudinal aging social survey.Archives of public health = Archives belges de sante publique · 2026Article
- Article
- Sensor-Equipped Digital Technologies for Monitoring and Detecting Depressive Disorders: A Systematic Review.Health science reports · 2026Review
- Article
- Innovations to improve outcomes and uptake of psychotherapies for mental disorders: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Bridging the service gap in cognitive behavioral therapy from a user perspective: Findings from a web-based survey in Japan.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Smartphone based cognitive behavioural therapy for adults with no or minimal depressive symptoms in Japan: an exploratory secondary analysis of RESiLIENT trial.The Lancet regional health. Western Pacific · 2025Article
- Associations of depression, anxiety, and insomnia symptoms in subthreshold depression: a network analysis.BMC psychiatry · 2025Article
- Rising cognitive behavioral therapy claims among Japanese youth despite population decline: A retrospective study using the National Database of Health Insurance Claims (FY 20142022).Global health & medicine · 2025Article
- Personalised & optimised therapy (POT) algorithm using five cognitive and behavioural skills for subthreshold depression.NPJ digital medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
Subthreshold depression, defined as a depressive status falling short of the diagnostic threshold for major depression, is common, disabling and constitutes a risk factor for future depressive episodes. Cognitive behavioral therapies (CBT) have been shown to be effective but are usually provided as packages of various skills. Little research has been done to investigate whether all their components are beneficial and contributory to mental health promotion. We addressed this issue by developing a smartphone CBT app that implements five representative CBT skills (behavioral activation, cognitive restructuring, problem solving, assertion training and behavior therapy for insomnia), and conducting a master randomized study that included four 2 × 2 factorial trials to enable precise estimation of skill-specific efficacies. Between September 2022 and February 2024, we recruited 3,936 adult participants with subthreshold depression. Among those randomized, the follow-up rate was 97% at week 6 and adherence to the app was 84%. The study showed that all included CBT skills and their combinations differentially beat all three control conditions of delayed treatment, health information or self-check, with effect sizes ranging between -0.67 (95% confidence interval: -0.81 to -0.53) and -0.16 (-0.30 to -0.02) for changes in depressive symptom severity from baseline to week 6, as measured with the Patient Health Questionnaire-9 scores. Knowledge of the active ingredients of CBT can better inform the design of more effective and scalable psychotherapies in the future. (UMIN Clinical Trials Registry UMIN000047124 ).
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