Evidence map›Paper›PMID 40269193›Full record

ArticleScientific reports2025

20:4-NAPE induced changes of mechanical sensitivity and DRG neurons excitability are concentration dependent and mediated via NAPE-PLD.

Anirban Bhattacharyya, Daniel Vasconcelos, Diana Spicarova, Jiri Palecek

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anirban BhattacharyyaLaboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0003-1077-2082
Daniel VasconcelosLaboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Diana SpicarovaLaboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0003-4268-2831
Jiri PalecekLaboratory of Pain Research, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Jiri.Palecek@fgu.cas.cz.ORCID http://orcid.org/0000-0002-0609-8542

Funding

European Union Next Generation EU LX22NPO5104Grant Agency of the Czech Republic 21-02371SInstitutional support RVO67985823
6 · The paper itself

Abstract

Alterations in the excitability of dorsal root ganglion (DRG) neurons are critical in the pathogenesis of acute and chronic pain. Neurotransmitter release from the terminals of DRG neurons is regulated by cannabinoid receptor 1 (CB

Indexed as

Arachidonic AcidsGanglia, SpinalNeuronsPhosphatidylethanolaminesPhospholipase DAnimalsCalciumEndocannabinoidsMalePolyunsaturated AlkamidesRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1TRPV Cation ChannelsanandamideArachidonic AcidsCalciumEndocannabinoidsPhosphatidylethanolaminesPhospholipase DPolyunsaturated AlkamidesReceptor, Cannabinoid, CB1Trpv1 protein, ratTRPV Cation Channels20:4-NAPEAnandamideCB1DRG neuronsNAPE-PLDTRPV1

Identifiers

PMID40269193
PMCPMC12019079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.