ArticleNature2025
BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Environmental cues signal through circadian control of sarcomeric gene expression during cardiomyocyte hypertrophy.Epigenetics · 2026Article
- BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review).Molecular medicine reports · 2026Review
- Stable clocks, rewired rhythms: circadian remodeling in skeletal muscle during aging, cachexia, and type 2 diabetes.Life metabolism · 2026Review
- The role of hypoxia-inducible factors in myocardial ischaemia-reperfusion injury and cardioprotection.Nature reviews. Cardiology · 2026Review
- Sensing Danger After Reperfusion: TLR7 as a Driver of Myocardial Injury.JACC. Basic to translational science · 2026Article
- Association Between Disruption of Blood Pressure Circadian Rhythm and Prognosis After Acute Anterior Myocardial Infarction.Clinical cardiology · 2026Article
- Timing the strain: skeletal muscle clock as regulator of physical activity.npj metabolic health and disease · 2026Review
- Fat body CLOCK restrains innate immunity and maintains survival under dietary stress inbioRxiv : the preprint server for biology · 2026Article
- Cardiovascular Consequences of Late-Gestational Hypoxia in Adult Female Rat Offspring and the Effects of Maternal Ergothioneine Treatment.Physiological research · 2026Article
- Circadian regulation of cardiovascular function: from physiology to clinical implications.Genome medicine · 2026Review
- Interplay between ischemia-reperfusion and metabolic reprogramming.Apoptosis : an international journal on programmed cell death · 2026Review
- BMAL1 attenuates myocardial infarction-induced fibrosis via suppressing p-SMAD3/SMAD3 in TGF-β1 pathway.Biochemistry and biophysics reports · 2026Article
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
- The CLOCK-BMAL1 complex in circadian regulation: structure, mechanisms, and therapeutic targeting.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Mitral stenosis severity and the hypoxic response: potential role of hypoxia-inducible factor-2α - a cross-sectional study.BMC cardiovascular disorders · 2026Article
- Integration of circadian and hypoxia signaling via non-canonical heterodimerization.FEBS letters · 2026Review
- HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm.Bone research · 2026Review
- BMAL1-GPX3 axis in the choroid plexus mitigates Aβ pathology in an amyloid mouse model.Journal of neuroinflammation · 2026Article
Corrections and comments
- Update of
Authors and funding
32 authors.
Wei Ruan *Department of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA. Wei.Ruan@uth.tmc.edu.ORCID 0000-0002-2718-7923
Tao Li *Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-3672-6906
In Hyuk Bang *Department of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-4666-7655
Jaewoong Lee *Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5731-3831
Wankun DengCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Xinxin MaDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-9942-9872
Cong LuoDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-5159-8343
Fang DuDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0001-8232-6693
Seung-Hee YooDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-9930-560X
Boyun KimDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-4973-6647
Jiwen LiDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-8595-860X
Xiaoyi YuanDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-2898-6495
Katherine FigarellaDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-3305-9167
Yu A AnDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Yin-Ying WangCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Yafen LiangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0001-7902-7836
Matthew DeBergeDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Dongze ZhangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Zhen ZhouDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Yanyu WangDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Joshua M GorhamDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5969-4690
Jonathan G SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9082-3566
Christine E SeidmanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6380-1209
Sary F ArankiDepartment of Surgery, Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ragini NairDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Lei LiInstitute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China.ORCID 0000-0003-3924-2544
Jagat NarulaDivision of Cardiology, Department of Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Memorial Hermann Hospital, Houston, TX, USA.
Zhongming ZhaoCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-3477-0914
Alemayehu A GorfeDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0002-9328-4692
Jochen D MuehlschlegelDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kuang-Lei TsaiDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA. kuang-lei.tsai@uth.tmc.edu.ORCID 0000-0002-5428-4219
Holger K EltzschigDepartment of Anesthesiology, Critical Care and Pain Medicine, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA. holger.eltzschig@uth.tmc.edu.ORCID 0000-0002-5676-6473
Funding
Research Training in AnesthesiaT32GM086287 · NIGMS · YALE UNIVERSITY · PI ROBERT SCHONBERGER · 2009 to 2026
$3.7MTransforming dbGaP genetic and genomic data to FAIR-ready by artificial intelligence and machine learning algorithmsR01LM012806 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongming Zhao · 2017 to 2026
$3.7MCardiac Exosomes in myocardial Ischemic injuryR01HL150401 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MUEHLSCHLEGEL, JOCHEN DANIEL · 2020 to 2024
$3.3MFunctional Role of HIF-PHDs in ARDSR01HL169519 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, Xiaoyi Yuan · 2023 to 2026
$2.7MCircadian Rhythm as a Therapeutic Target for Perioperative CardioprotectionR01HL165748 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Holger K. Eltzschig, JOCHEN DANIEL MUEHLSCHLEGEL · 2023 to 2026
$2.6MGenetics of gene expression in human left ventricular myocardiumR01HL118266 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MUEHLSCHLEGEL, JOCHEN DANIEL · 2013 to 2017
$2.3MmicroRNA miR-147 Dampens Alveolar Epithelial Inflammation During ARDSR01HL154720 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2021 to 2024
$2.2MMammalian circadian rhythms: from genes to mechanismsR35GM145232 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Seung-Hee Yoo · 2022 to 2026
$2.2MTargeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress SyndromeR01HL155950 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xiaoyi Yuan · 2022 to 2026
$2.0MStructural insights into the Argonaute-containing CDK8 complexR01GM143587 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TSAI, KUANG-LEI · 2021 to 2025
$1.7MAmphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5MDynamics of lipid-anchored proteinsR01GM144836 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GORFE, ALEMAYEHU A. · 2022 to 2025
$1.4MNHLBI NIH HHS R01 HL118266NHLBI NIH HHS R01 HL119837NHLBI NIH HHS R01 HL150401NHLBI NIH HHS R01 HL154720NHLBI NIH HHS R01 HL155950NHLBI NIH HHS R01 HL165748NHLBI NIH HHS R01 HL169519NHLBI NIH HHS R35 HL177402NIGMS NIH HHS R01 GM143587NIGMS NIH HHS R01 GM144836NIGMS NIH HHS R35 GM145232NIGMS NIH HHS T32 GM086287NIGMS NIH HHS T32 GM135118NLM NIH HHS R01 LM012806
Abstract
Acute myocardial infarction is a leading cause of morbidity and mortality worldwide
Indexed as
ARNTL Transcription FactorsBasic Helix-Loop-Helix ProteinsCircadian RhythmMyocardial InfarctionProtein MultimerizationAnimalsCell HypoxiaCryoelectron MicroscopyDNAEndothelial PAS Domain-Containing Protein 1FemaleHumansHypoxiaMaleMiceMice, Inbred C57BLARNTL Transcription FactorsBasic Helix-Loop-Helix ProteinsBMAL1 protein, humanBmal1 protein, mouseDNAEndothelial PAS Domain-Containing Protein 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.