Evidence map›Paper›PMID 40269164›Full record

ArticleNature2025

A distributed coding logic for thermosensation and inflammatory pain.

Nima Ghitani, Lars J von Buchholtz, Donald Iain MacDonald, Melanie Falgairolle, Minh Q Nguyen, Julia A Licholai, Nicholas J P Ryba, Alexander T Chesler

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. TRPM2 is a direct pain transducer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Functional and molecular diversity of human C-fibers in pain modulation.Current opinion in supportive and palliative care · 2026
    Review
  4. An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Article
  12. Review
  13. A Reference Atlas of the Human Dorsal Root Ganglion.bioRxiv : the preprint server for biology · 2025
    Article
  14. Nociceptors use multiple neurotransmitters to drive pain.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nima Ghitani *National Center for Complementary and Integrative Health, Bethesda, MD, USA.
Lars J von Buchholtz *National Institute of Dental and Craniofacial Research, Bethesda, MD, USA.
Donald Iain MacDonaldNational Center for Complementary and Integrative Health, Bethesda, MD, USA.
Melanie FalgairolleNational Center for Complementary and Integrative Health, Bethesda, MD, USA.ORCID 0000-0001-5243-4714
Minh Q NguyenNational Institute of Dental and Craniofacial Research, Bethesda, MD, USA.
Julia A LicholaiNational Institute of Dental and Craniofacial Research, Bethesda, MD, USA.
Nicholas J P RybaNational Institute of Dental and Craniofacial Research, Bethesda, MD, USA. nick.ryba@nih.gov.ORCID 0000-0002-2060-8393
Alexander T CheslerNational Center for Complementary and Integrative Health, Bethesda, MD, USA. alexander.chesler@nih.gov.ORCID 0000-0002-3131-0728

Funding

Taste And SmellZIADE000561 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI RYBA, NICHOLAS J · 2009 to 2025
$26.2M
Gene Transfer Core, NIDCR-DIRZICDE000744 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KULKARNI, ASHOK · 2014 to 2023
$12.1M
Studies on the molecular, cells, and circuit that underlie somatosensation and painZIAAT000028 · NCCIH · NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH · PI CHESLER, ALEXANDER · 2014 to 2025
$12.0M
Intramural NIH HHS ZIA AT000028Intramural NIH HHS ZIA DE000561Intramural NIH HHS ZIC DE000744
6 · The paper itself

Abstract

Somatosensory neurons encode detailed information about touch and temperature and are the peripheral drivers of pain

Indexed as

InflammationPainThermosensingAnimalsDinoprostoneFemaleHot TemperatureHyperalgesiaMaleMiceMice, Inbred C57BLNociceptorsPhysical StimulationRatsTouchTRPV Cation ChannelsDinoprostoneTRPV Cation Channels

Identifiers

PMID40269164
PMCPMC12222022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.