Evidence map›Paper›PMID 40269159›Full record

ArticleNature2025

Deciphering disordered regions controlling mRNA decay in high-throughput.

Joseph H Lobel, Nicholas T Ingolia

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Phosphorylation-dependent tuning of mRNA deadenylation rates.Nature structural & molecular biology · 2026
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Joseph H LobelDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-5986-7280
Nicholas T IngoliaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. ingolia@berkeley.edu.ORCID 0000-0002-3395-1545

Funding

Functional genomics of the dynamic molecular network controlling mRNA translation and decayR01GM130996 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI INGOLIA, NICHOLAS T · 2019 to 2022
$1.2M
Pacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600k
Principles and Properties of Disordered Regions in Post-Transcriptional ControlF32GM148044 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LOBEL, JOSEPH HEIMLICH · 2022 to 2023
$139k
NIGMS NIH HHS F32 GM148044NIGMS NIH HHS R01 GM130996NIH HHS S10 OD018174
6 · The paper itself

Abstract

Intrinsically disordered regions within proteins drive specific molecular functions despite lacking a defined structure

Indexed as

High-Throughput Screening AssaysIntrinsically Disordered ProteinsRNA, MessengerRNA StabilityHumansMachine LearningMutagenesisProtein BiosynthesisIntrinsically Disordered ProteinsRNA, Messenger

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.