Evidence map›Paper›PMID 40269130›Full record

ArticleScientific reports2025

Investigating the protective effect of hydroxylated fullerenes on cognitive function in rats with temporal lobe epilepsy.

Xiaoqing Wang, Shuang Tian, Zhenzhen Qu, Ran Meng, Guangxiao Ni, Min Liu, Huifang Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoqing WangThe Department of Rehabilitation, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Shuang TianThe Department of Neurology, Shijiazhuang People's Hospital, Shijiazhuang, Hebei, People's Republic of China.
Zhenzhen QuThe Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Ran MengThe Department of Rehabilitation, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Guangxiao NiThe Department of Rehabilitation, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Min LiuThe Department of Rehabilitation, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Huifang CaoThe Department of Rehabilitation, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. caohuifang@hebmu.edu.cn.ORCID http://orcid.org/0000-0002-0785-0214

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to explore the protective effects of hydroxy fullerenes (HFs) on cognitive function in rats with temporal lobe epilepsy (TLE) and to elucidate the underlying mechanisms. Eighteen Sprague-Dawley (SD) rats were randomly selected and administered pilocarpine (50 mg/kg) intraperitoneally to establish a TLE model, and were then randomly assigned to the TLE group and the TLE + HFs group. An additional nine SD rats were served as a normal control group (CON group). The Morris water maze (MWM) test was utilized to assess the spatial learning and memory capabilities of the rats. Nissl staining was employed to observe the survival neurons in the CA1 and CA3 regions. In addition, the ultrastructure of synapses in the CA1 region was examined using transmission electron microscopy (TEM). The expressions of postsynaptic densitin-95 (PSD-95) and synaptophysin (SYP) in the hippocampus were detected via western blotting. The findings revealed that compared to the CON group, the TLE group exhibited significantly prolonged escape latency, reduced platform crossing frequency, and shortened time spent in the target quadrant. The number of surviving neurons in the CA1 and CA3 regions and the expression of PSD95 and SYP protein were significantly decreased (P < 0.05 or P < 0.001). However, these alterations were reversed in the TLE + HFs group. It is suggested that HFs may enhance the spatial learning and memory ability of TLE rats by preserving the integrity of hippocampal neurons, up-regulating the expression of SYP and PSD95 in hippocampus.

Indexed as

CognitionEpilepsy, Temporal LobeFullerenesNeuroprotective AgentsAnimalsDisease Models, AnimalDisks Large Homolog 4 ProteinHippocampusMaleMaze LearningNeuronsPilocarpineRatsRats, Sprague-DawleySynapsesSynaptophysinDisks Large Homolog 4 ProteinDlg4 protein, ratFullerenesNeuroprotective AgentsPilocarpineSynaptophysinCognitive functionHydroxylated fullerenesPostsynaptic density protein-95SynaptophysinTemporal lobe epilepsy

Identifiers

PMID40269130
PMCPMC12019555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.