ArticleScientific reports2025
Blood glucose reduction associated with wholewheat noodle diet in rats with type 2 diabetes mellitus.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Wheat Bioactive Compounds and Human Health: A Review of Nutraceutical Potential, Molecular Mechanisms and AI-Assisted Functional Food Innovation.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The blood glucose reducing effects of wholewheat noodles in a type 2 diabetes mellitus (T2DM) rat model were investigated. The T2DM model was established by feeding the rats a high-fat diet and injection of streptozotocin solution. Three treatment groups were used, in which the model rats were fed low-, medium-, or high-fiber wholewheat noodles (LF, MF, and HF, respectively). Fasting blood glucose, the organ coefficient, oxidative stress, pathological changes, and intestinal microbiota were examined. The wholewheat noodles reduced blood glucose, with the high-fiber diet achieving the greatest effect. Wholewheat noodle intake increased total antioxidant capacity as well as superoxide dismutase, glutathione peroxidase, and catalase activity in the liver and reduced malondialdehyde content. Increasing the fiber content increased intestinal microbiota species richness and diversity and improved intestinal microbiota composition. The wholewheat diets were associated with upregulated gene expression of insulin receptor, insulin receptor substrate 2, and glucose transporter 2 and of the downstream signaling molecules protein kinase B and 3-phosphoinositide-dependent kinase 1. The wholewheat diet downregulated phosphatidylinositol-3-kinase (PI3K) regulatory subunit p85 gene expression and in turn enhanced insulin-activated PI3K signaling and glucose uptake and utilization in liver tissues, thus reducing blood glucose. Therefore, the blood glucose reducing effects of wholewheat noodles increase as their fiber content increases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.