ArticleScientific reports2025
Association between systemic immune-inflammation index and chronic bronchitis: NHANES 2001-2018.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Comparison and validation of systemic immune-inflammation index, C-reactive protein/albumin ratio, and C-reactive protein-albumin-lymphocyte index for assessing disease activity in rheumatoid arthritis.Clinical rheumatology · 2026Article
- Association between psoriasis and chronic bronchitis: Adverse reaction to therapy or neglected comorbidity?Journal of biomedical research · 2026Article
- Association of the high-density lipoprotein cholesterol to C-reactive protein ratio with chronic cough in US adults: Effect modification by smoking status.Tobacco induced diseases · 2026Article
- The predictive value of baseline systemic inflammation response index and systemic immune-inflammation index for the risk of infection within 6 months following initial immunosuppressive treatment in patients with ANCA-associated vasculitis.Frontiers in immunology · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The systemic immune-inflammation index (SII) is a newly identified marker of inflammation., and the relationship between chronic bronchitis (CB) and inflammation is closely associated. However, the influence of SII on CB remains unclear at present.This cross-sectional study was conducted using data from individuals with complete SII and CB records from the 2001-2018 National Health and Nutrition Examination Survey (NHANES). Binary weighted logistic regression was employed to investigate the relationship between SII and CB risk. Additionally, restricted cubic spline regression models and segmented regression models were used to examine nonlinear relationships and threshold effects. Receiver operating characteristic (ROC) curves were adopted to evaluate the predictive value of SII for CB. Stratified analysis was adopted to assess the association between SII and CB in different populations. After adjusting for all covariables, there was a significant positive relevance observed between log-transformed SII (log (SII)) with CB (OR = 1.52, 95% CI: 1.27-1.82, P < 0.001). A nonlinear dose-response relationship with the threshold of 8.14 was observed between log (SII) and CB risk. When log (SII) exceeded 8.14, each unit increase in log (SII) was associated with a 1.31-fold increase in the risk of CB (OR = 1.31, 95% CI: 1.22-1.40, P < 0.001). Furthermore, ROC curves revealed strong predictive capability of SII for CB (AUC = 0.729). Elevated SII levels are associated with an increased prevalence of CB. Furthermore, a non-linear association exists between SII and the increased risk of CB.
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