Evidence map›Paper›PMID 40269050›Full record

ArticleScientific reports2025

Heavy metal exposures in aerodigestive clinic cohort of infants with reflux or dysphagia.

Nan Du, Maritha Du, Tracy Punshon, Rachel Rosen

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nan DuDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA. nan.du@childrens.harvard.edu.
Maritha DuDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.
Tracy PunshonDepartment of Biological Sciences, Dartmouth College, Hanover, NH, USA.
Rachel RosenDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, USA.

Funding

TRAINING IN PEDIATRIC GASTROENTEROLOGY &NUTRITIONT32DK007477 · NIDDK · CHILDREN'S HOSPITAL BOSTON · PI Scott B Snapper · 1986 to 2026
$13.3M
The impact of upper gastrointestinal dysmotility on aspiration-associated aerodigestive disorders in childrenR01DK097112 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Rachel L Rosen · 2015 to 2026
$4.9M
Laying the Groundwork for Web-based Elemental Imaging Software: The MicroAnalysis ToolkitR24GM141194 · NIGMS · DARTMOUTH COLLEGE · PI Brian P Jackson · 2021 to 2026
$3.1M
National Science Foundation 2042513NIDDK NIH HHS R01 DK097112NIDDK NIH HHS T32 DK007477NIDDK NIH HHS T32DK007477NIGMS NIH HHS 1R24GM141194NIGMS NIH HHS R24 GM141194NIH HHS R01DK 97112
6 · The paper itself

Abstract

Infant cereals (rice/oatmeal), purees, and anti-reflux formulas are often first line treatments for thickening in infants with reflux and oropharyngeal dysphagia. However, there has been growing concern about heavy metal contamination, especially arsenic, in these commonly used thickeners. This is a particular concern in infants who may be more susceptible to heavy metal neurotoxicity. The study aimed to assess whether there are differences in heavy metal levels, particularly arsenic, in infants with reflux or oropharyngeal dysphagia while on different thickeners. We performed a single center study in infants (< 1 year of age) with diagnosis of reflux or oropharyngeal dysphagia who were seen between December 2021-2023. Participants submitted urine samples and completed dietary questionnaires to assess their elemental exposures. The primary outcome of interest was urinary arsenic concentrations, though other elements were also measured. Of the 56 infants, 27 were on gelmix

Indexed as

Deglutition DisordersGastroesophageal RefluxMetals, HeavyArsenicCohort StudiesFemaleFood ContaminationHumansInfantInfant, NewbornMaleArsenicMetals, HeavyArsenicDysphagiaMolybdenumRefluxToxic elements

Identifiers

PMID40269050
PMCPMC12019543

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.