Evidence map›Paper›PMID 40269015›Full record

ArticleScientific reports2025

Process intensification of cultivated meat production through microcarrier addition strategy optimisation.

Vincent Bodiou, Nicolas Cristini, Lucrezia De Cristofaro, Tirusha Pareek, Varun Rajagopal, Lola Verrougstraete, Josué M Heinrich, Mark J Post, Panagiota Moutsatsou

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Edible Sulfonated Soy Protein Microcarriers for Cultivated Meat Cell Expansion.Journal of biomedical materials research. Part A · 2026
    Article
  5. Article
  6. Edible Scaffolds for Cultivated Meat Production.Advances in biochemical engineering/biotechnology · 2026
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vincent BodiouMosa Meat BV, Maastricht, Netherlands.
Nicolas CristiniMosa Meat BV, Maastricht, Netherlands.
Lucrezia De CristofaroMosa Meat BV, Maastricht, Netherlands.
Tirusha PareekMosa Meat BV, Maastricht, Netherlands.
Varun RajagopalMosa Meat BV, Maastricht, Netherlands.
Lola VerrougstraeteMosa Meat BV, Maastricht, Netherlands.
Josué M HeinrichMosa Meat BV, Maastricht, Netherlands.
Mark J PostMosa Meat BV, Maastricht, Netherlands.
Panagiota MoutsatsouMosa Meat BV, Maastricht, Netherlands. p.moutsatsou@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of microcarriers (MCs) is currently the most promising method for scaling up bovine satellite cell (bSC) cultures for cultivated meat production. Thanks to the inherent ability of the cells to migrate from one MC to another, also known as bead-to-bead transfer, the need for cell detachment is limited to a minimum, leading to a seamless seeding train. With this study, we aim to intensify the bioprocessing of bSCs in serum-free medium, by exploring the parameters influencing bead-to-bead transfer and cell growth and by optimising the seeding conditions and the MC addition strategy. Keeping production scale bioprocessing requirements into consideration, such as maximisation of fold increase within the same system, we have grown bSCs in up to 80 cm

Indexed as

Cell Culture TechniquesMeatSatellite Cells, Skeletal MuscleAnimalsBioreactorsCattleCell CountCell ProliferationCells, CulturedIn Vitro MeatBead-to-bead transferBioprocessingBioreactor cultivationMicrocarrierSatellite cellsScale up

Identifiers

PMID40269015
PMCPMC12019398

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.