Evidence map›Paper›PMID 40268960›Full record

Observational studyScientific reports2025

Angiotensin converting enzyme 2 in patients with sepsis associate with comorbidities but neither with mortality nor with organ failure.

Felix Forsberg, Toralph Ruge, Anders Larsson, Per Wändell, Axel C Carlsson, Peter M Nilsson, Per Swärd

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Felix ForsbergClinical and Molecular Osteoporosis Research Unit, Departments of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden. felix.forsberg@skane.se.
Toralph RugeDepartment of Clinical Sciences Malmö & Department of Internal Medicine, Skåne University Hospital, Lund University, Malmö, Sweden.
Anders LarssonDepartment of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Per WändellDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels Allé 23, 141 83, Huddinge, Sweden.
Axel C CarlssonDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, Alfred Nobels Allé 23, 141 83, Huddinge, Sweden.
Peter M NilssonDepartment of Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden.
Per SwärdClinical and Molecular Osteoporosis Research Unit, Departments of Orthopedics and Clinical Sciences, Skåne University Hospital, Lund University, 205 02, Malmö, Sweden. Per.sward@skane.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High levels of circulating angiotensin converting enzyme 2 (ACE2) are associated with several chronic diseases and mortality risk. Less is known about the prognostic value of ACE2 in patients with sepsis. In the present study, we aimed to investigate the association between plasma ACE2 levels on admission to the ED and 28-day mortality, organ failure, and level of care in a prospectively recruited observational study sample. Six hundred patients with sepsis admitted to the emergency in Malmö 2013-2015 were included in the analysis. Uni- and multivariable binary logistic regression was conducted to investigate the association between ACE2 and 28-day mortality, organ failure, and level of care. Plasma ACE2 levels were increased in patients with male sex, high age, and comorbidities, including diabetes, cardiovascular disease, and cancer. Plasma ACE2 levels associated with hospitalization and intermediate care unit stay in univariate but not multivariate analysis. Plasma ACE2 did neither associate with 28-day mortality, OR 1.19 (95% CI 0.86-1.65, p = 0.29), nor with organ failure, OR 1.08 (95% CI 0.73-1.56. p = 0.72). Future studies investigating the dynamics of circulating ACE2 levels in patients with sepsis longitudinally are warranted.

Indexed as

Multiple Organ FailurePeptidyl-Dipeptidase ASepsisAgedAged, 80 and overAngiotensin-Converting Enzyme 2BiomarkersComorbidityFemaleHumansMaleMiddle AgedPrognosisProspective StudiesACE2 protein, humanAngiotensin-Converting Enzyme 2BiomarkersPeptidyl-Dipeptidase AAngiotensin converting enzyme 2 (ACE2)ComorbiditiesLevel of careMortalityOrgan failureSepsis

Identifiers

PMID40268960
PMCPMC12019403

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.