ArticleNPJ vaccines2025
Poliovirus shedding after sequential immunization of Sabin-strain inactivated polio vaccines and oral attenuated polio vaccines.
Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- MS2 virus-like particles as a versatile platform for multi-disease vaccines: a review.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
49 authors.
Funding
Abstract
The identification of poliovirus in stool samples post-Oral Poliovirus Vaccine (OPV) immunization is essential for implementing post-eradication monitoring of poliomyelitis. This research presents the inaugural assessment of the virus shedding rate and the genetic diversity of OPV shedding strains across different Inactivated Poliovirus Vaccine (IPV)-OPV sequential immunization schedules. Our findings revealed that the shedding rate of different serotypes in each sequential immunization groups peaked within 7 days following the initial administration of OPV, and then gradually decreased. Prior vaccination with OPV reduced the rate and shortened the duration of virus shedding. Additionally, we observed a slight increase in the shedding rate of type3 after the removal of type2 from trivalent oral poliovirus vaccine (tOPV). The comprehensive analysis of the whole-genome high-throughput sequencing results for the shedding strain revealed that the variation sites among samples from different sequential immunization groups were distributed throughout the entire genome. The mutation frequencies within the 5'NCR, 2 C, 3 A, 3 C, and 3D regions were elevated of type1 and type3, while type2 had higher frequencies within the 5'NCR, VP1 and 3D regions. Consequently, it is imperative to expedite the transition from OPV to IPV, and to discontinue OPV as soon as wild poliovirus strains and vaccine-derived poliovirus (VDPVs) are eliminated.
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Registered trials
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