Evidence map›Paper›PMID 40268938›Full record

ArticleNPJ Parkinson's disease2025

Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein.

Hope Pan, Melinda Balbirnie, Ke Hou, Naomi S Sta Maria, Shruti Sahay, Paul Denver, Stefano Lepore, Mychica Jones, Xiaohong Zuo, Chunni Zhu and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Hope Pan *Department of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Melinda Balbirnie *Department of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Ke HouDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Naomi S Sta MariaDepartment of Research Physiology, Department of Neuroscience, Keck School of Medicine at USC, Los Angeles, CA, USA.
Shruti SahayDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Paul DenverGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
Stefano LeporeDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Mychica JonesGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
Xiaohong ZuoGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
Chunni ZhuDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Hilda MirbahaDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Hedieh Shahpasand-KronerGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
Marisa MekkittikulGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
Jiahui LuDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Carolyn J HuDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Xinyi ChengDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Romany AbskharonDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Michael R SawayaDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA.
Christopher K WilliamsDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Harry V VintersDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Russell E JacobsDepartment of Research Physiology, Department of Neuroscience, Keck School of Medicine at USC, Los Angeles, CA, USA.
Neil G HarrisDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Gregory M ColeGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
Sally A FrautschyGeriatric Research Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, West Los Angeles VA Medical Center, Los Angeles, CA, USA.
David S EisenbergDepartment of Chemistry and Biochemistry, Department of Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, UCLA, Los Angeles, CA, USA. david@mbi.ucla.edu.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
CHEMISTRY BIOLOGY INTERFACE TRAINING PROGRAMT32GM008496 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYNARD, HEATHER D · 1993 to 2019
$6.3M
Metabolic and Vascular Factors in tau pathogenesisR01AG066212 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FRAUTSCHY, SALLY ANN · 2020 to 2024
$3.4M
Designing novel therapeutics for Alzheimer’s disease using structural studies of tauF30AG077832 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAN, HOPE · 2023 to 2025
$141k
BLRD VA I01 BX005919Michael J. Fox Foundation for Parkinson's Research MJFF-001065Michael J. Fox Foundation for Parkinson's Research MJFF-005905NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1TR001881NIA NIH HHS 1F30AG077832-01A1NIA NIH HHS F30 AG077832NIA NIH HHS R01 AG066212NIGMS NIH HHS T32 GM008042NIGMS NIH HHS T32 GM008496
6 · The paper itself

Abstract

Aggregation of the protein α-synuclein (α-syn) is the histopathological hallmark of neurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), which are collectively known as synucleinopathies. Currently, patients with synucleinopathies are diagnosed by physical examination and medical history, often at advanced stages of disease. Because synucleinopathies are associated with α-syn aggregates, and α-syn aggregation often precedes onset of symptoms, detecting α-syn aggregates would be a valuable early diagnostic for patients with synucleinopathies. Here, we design a liganded magnetic nanoparticle (LMNP) functionalized with an α-syn-targeting peptide to be used as a magnetic resonance imaging (MRI)-based biomarker for α-syn. Our LMNPs bind to aggregates of α-syn in vitro, cross the blood-brain barrier in mice with mannitol adjuvant, and can be used as an MRI contrast agent to distinguish mice with α-synucleinopathy from age-matched, wild-type control mice in vivo. These results provide evidence for the potential of magnetic nanoparticles that target α-syn for diagnosis of synucleinopathies.

Identifiers

PMID40268938
PMCPMC12019173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.