Evidence map›Paper›PMID 40268926›Full record

ArticleSchizophrenia (Heidelberg, Germany)2025

Aberrant aging-associated p62 autophagic cascade in biopsied olfactory neuronal cells from patients with psychosis.

Kun Yang, Koko Ishizuka, Toshifumi Tomoda, Akira Sawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kun Yang *Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Koko Ishizuka *Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Toshifumi TomodaCentre for Addiction and Mental Health, Department of Psychiatry, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5T 1R8, Canada.
Akira SawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. asawa1@jhmi.edu.ORCID http://orcid.org/0000-0003-1401-3008

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Project 3P50MH136297 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Akira Sawa · 2024 to 2026
$12.8M
High throughput marker for cognitive deficit: cellular autofluorescenceR01MH107730 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2018 to 2022
$3.0M
Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre) 470458NIMH NIH HHS P50 MH094268NIMH NIH HHS P50 MH136297NIMH NIH HHS R01 MH107730U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH-094268, MH-107730, MH-129480, and MH-13629
6 · The paper itself

Abstract

Sequestosome-1/p62, a key mediator in the clearance of damaged organelles and macromolecules during autophagy, serves as a marker of biological aging. We demonstrate elevated p62 in biopsied neuronal cells in patients with psychosis compared to healthy controls. In healthy controls, p62-indicated biological/autophagic age is positively correlated with chronological age over time, whereas in patients, neuronal p62-indicated biological/autophagic age shows no correlation with chronological age, being significantly higher than chronological age from the onset of the disease.

Identifiers

PMID40268926
PMCPMC12019308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.