Evidence map›Paper›PMID 40268886›Full record

ArticlePhysiological reports2025

Gasdermin D mutation protects against renal ischemia reperfusion injury.

Jennifer S Y Li, Aadhar Moudgil, Daniel N Meijles, Karli Shaw, Sohel M Julovi, Katie Trinh, Stephen I Alexander, Natasha M Rogers

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jennifer S Y LiCentre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia.
Aadhar MoudgilCentre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia.
Daniel N MeijlesMolecular and Clinical Science Institute, St George's, University of London, London, UK.
Karli ShawSydney Medical School, Faculty of Health and Medicine, University of Sydney, Camperdown, Australia.
Sohel M JuloviCentre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia.
Katie TrinhCentre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia.
Stephen I AlexanderSydney Medical School, Faculty of Health and Medicine, University of Sydney, Camperdown, Australia.
Natasha M RogersCentre for Transplant and Renal Research, Westmead Institute for Medical Research, Westmead, Australia.ORCID 0000-0003-2456-9544

Funding

National Health and Medical Research Council (NHMRC)Westmead Association BJ Amos Travelling Scholarship
6 · The paper itself

Abstract

Pyroptosis, the most inflammatory form of cell death, is dependent on membrane pore formation governed by the assembly of cleaved Gasdermin D (GSDMD). We hypothesized that regulated necrosis pathways are crucial in the pathophysiology of acute kidney injury (AKI). Mice with an isoleucine-to-asparagine loss-of-function mutation in the Gasdermin D gene (GSDMD

Indexed as

Acute Kidney InjuryIntracellular Signaling Peptides and ProteinsKidneyPhosphate-Binding ProteinsReperfusion InjuryAnimalsDisulfiramGasderminsMaleMiceMice, Inbred C57BLMutationOxidative StressPyroptosisDisulfiramGasderminsGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding Proteinsacute kidney injurygasdermin Drenal tubular epithelial cells

Identifiers

PMID40268886
PMCPMC12018169

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.