Evidence map›Paper›PMID 40268847›Full record

ArticleAnnals of surgical oncology2025

Risk Classification of Oral Cancer Surgical Margins: Margin to Depth of Invasion Ratio Analysis.

Chun-Yang Hung, Li-Jen Liao, Yu-Ping Cheng, Wan-Lun Hsu, Chun-Ju Chiang, Chun-Wei Chang, Wen-Chung Lee, Cheng-Ping Wang, Pei-Jen Lou, Yih-Leong Chang and 1 more

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chun-Yang Hung *Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (ROC).
Li-Jen Liao *Department of Otolaryngology Head and Neck Surgery, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Yu-Ping ChengData Science Center, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Wan-Lun HsuData Science Center, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan.
Chun-Ju ChiangGraduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Chun-Wei ChangDepartment of Otolaryngology, National Taiwan University BioMedical Park Hospital, Hsin-Chu, Taiwan.
Wen-Chung LeeGraduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Cheng-Ping WangDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (ROC).
Pei-Jen LouDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (ROC).
Yih-Leong ChangDepartment of Pathology, National Taiwan University Cancer Center and National Taiwan University College of Medicine, Taipei, Taiwan.
Tseng-Cheng ChenDepartment of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (ROC). tcchen0102@ntu.edu.tw.

Funding

Health Promotion Administration, Ministry of Health and Welfare A1121004
6 · The paper itself

Abstract

backgroundA high-risk margin is a recurrence risk factor in oral squamous cell carcinoma (OSCC), but its exact definition is debated. The effectiveness of the margin-to-depth-of-invasion ratio (MDR) in identifying high-risk margin remains to be determined.

methodsPatients who had a diagnosis of pT1-4N0 OSCC with negative margins (margin > 1 mm) recorded in the Taiwan Cancer Registry between January 2018 and December 2021 were reviewed. All patients were categorized into two groups: MDR < 0.5 and MDR ≥ 0.5.

resultsThe study analyzed 7420 OSCC patients without a positive margin. Of these 7420 patients, 4669 (62.92%) had an MDR ≥ 0.5, and 2751 (37.08%) had an MDR < 0.5. The group with an MDR < 0.5 exhibited significantly poorer 3-year disease-free survival (DFS, 74% vs 86%) and overall survival (OS, 79% vs 89%) than the group with an MDR ≥ 0.5. Despite a higher rate of postoperative radiotherapy (PORT) in the group with an MDR < 0.5, multivariate Cox analysis showed that patients with a margin < 5 mm and an MDR ≥ 0.5 had a significantly better DFS than those with a margin < 5 mm and an MDR < 0.5 (p = 0.001). Treatment with PORT improved DFS and OS for the patients with an MDR < 0.5, but worsened outcomes for the patients with an MDR ≥ 0.5.

conclusionFor OSCC patients without positive margin, an MDR < 0.5 was associated with worse survival and higher locoregional recurrence risk. The patients with an MDR < 0.5 may benefit from PORT, whereas those with an MDR ≥ 0.5 could experience worse outcomes. An MDR < 0.5 could serve as a criterion for high-risk OSCC margin.

Indexed as

Carcinoma, Squamous CellMargins of ExcisionMouth NeoplasmsNeoplasm Recurrence, LocalAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisRetrospective StudiesRisk FactorsClose marginDepth of invasionDisease-free survivalLocal recurrenceMargin-to-depth-of-invasion ratioOral squamous cell carcinomaOverall survival

Identifiers

PMID40268847

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.