ArticleActa neurochirurgica2025
Reducing cerebrospinal fluid leak in vestibular schwannoma surgery via a retrosigmoid approach: a retrospective clinical study.
Article in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Salvage surgery following primary treatment in recurrent vestibular schwannoma: surgical outcomes and progression-free survival- a meta-analysis.Journal of neuro-oncology · 2026Pooled it
- A Stitch in Time Saves Nine: Retrosigmoid Craniotomy with Layered Suboccipital Muscle Dissection to Prevent Cerebrospinal Fluid Leak and Infection.Journal of neurological surgery. Part B, Skull base · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCerebrospinal fluid leak can occur after retrosigmoid craniectomy and lead to substantial patient morbidity. The aim of this study was to compare two closure techniques for vestibular schwannoma resection in terms of cerebrospinal fluid leak and other procedure-related issues.
methodsThis retrospective monocentric study included patients who underwent surgery for vestibular schwannoma resection via a retrosigmoid approach by the same oto-neurosurgical team. Before 2019, the retrosigmoid approach consisted of a craniectomy and the closure involved autologous abdominal fat graft obliteration (previous procedure). After 2019, the authors performed a craniotomy and used S53P4 bioactive glass granules to close the craniotomy site (new procedure).
resultsWe included 193 patients, 79 with the previous procedure and 114 the new procedure. Cerebrospinal fluid leak developed postoperatively in 3 patients with the new procedure and 14 with the previous procedure (p < 0.01). Need for surgical revision to treat the leak was lower with the new than previous procedure (1 vs 6 patients, p = 0.02) and the median length of hospital stay was reduced by 2 days with the new procedure (< 0.001).
conclusionThe craniotomy/bioactive glass obliteration technique was associated with less cerebrospinal fluid leak as compared with craniectomy/autologous fat graft obliteration, less revision surgery and a shorter hospital stay.
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