Evidence map›Paper›PMID 40268745›Full record

ReviewGenomics, proteomics & bioinformatics2025

CRISPR Technology and Its Emerging Applications.

Xuejing Zhang, Dongyuan Ma, Feng Liu

Abstract readReview
In one paragraph

Review in Genomics, proteomics & bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Towards deployable CRISPR-based nucleic acid detection.Progress in biomedical engineering (Bristol, England) · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xuejing ZhangShandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266237, China.ORCID 0009-0009-0693-1774
Dongyuan MaState Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute for Stem Cell and Regenerative Medicine, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100101, China.ORCID 0000-0002-9710-5970
Feng LiuShandong Provincial Key Laboratory of Animal Cell and Developmental Biology, School of Life Sciences, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266237, China.ORCID 0000-0003-3228-0943

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The discovery and iteration of clustered regularly interspaced short palindromic repeats (CRISPR) systems have revolutionized genome editing due to their remarkable efficiency and easy programmability, enabling precise manipulation of genomic elements. Owing to these unique advantages, CRISPR technology has the transformative potential to elucidate biological mechanisms and develop clinical treatments. This review provides a comprehensive overview of the development and applications of CRISPR technology. After describing the three primary CRISPR-Cas systems - CRISPR-associated protein 9 (Cas9) and Cas12a targeting DNA, and Cas13 targeting RNA - which serve as the cornerstone for technological advancements, we describe a series of novel CRISPR-Cas systems that offer new avenues for research, and then explore the applications of CRISPR technology in large-scale genetic screening, lineage tracing, genetic diagnosis, and gene therapy. As this technology evolves, it holds significant promise for studying gene functions and treating human diseases in the near future.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsGene EditingAnimalsGenetic TherapyHumansCRISPRGene functionGene therapyGenome editingLineage tracing

Identifiers

PMID40268745
PMCPMC12449060

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.