Evidence map›Paper›PMID 40268681›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-

Stephen J McBride, Megan Pike, Erica Curran, Alexander Zavriyev, Bukola Adebesin, Luke Tucker, Jared M Harzan, Ishani M Senanayake, Mustapha Abdulmojeed, Franziska Theiss and 12 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Exploring Limits of [1-Small science · 2026
    Article
  3. Article
  4. Article
  5. Biocompatible SABRE Hyperpolarization of [1-Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  6. High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  7. Article
  8. Hyperpolarization of [1-Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Ultra-low fieldCommunications chemistry · 2026
    Article
  13. Benchtop NMR signal enhancement of metabolites in urine extract using SABRE.Chemical communications (Cambridge, England) · 2026
    Article
  14. Review
  15. Article
  16. Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025
    Article
  17. SABRE Ir-IMes Catalysis for the Masses.Molecules (Basel, Switzerland) · 2025
    Article
  18. Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025
    Article
  19. SABRE-SHEATH hyperpolarizedChemical communications (Cambridge, England) · 2025
    Article
  20. Hyperpolarized MRI theranostics in cancer.Frontiers in oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Stephen J McBride *Department of Chemistry, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0001-9144-1423
Megan Pike *Department of Chemistry, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0002-2896-5408
Erica Curran *Department of Chemistry, North Carolina State University, Raleigh, NC, USA.
Alexander ZavriyevDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Bukola AdebesinDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Luke TuckerVizma Life Sciences, Chapel Hill, NC, 27514, USA.
Jared M HarzanSchool of Chemical & Biomolecular Sciences, Southern Illinois University, Carbondale, IL, USA.
Ishani M SenanayakeSchool of Chemical & Biomolecular Sciences, Southern Illinois University, Carbondale, IL, USA.
Mustapha AbdulmojeedDepartment of Chemistry, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0002-5513-3658
Franziska TheissDepartment of Chemistry, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0001-6779-9978
Sheng ShenA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0002-4320-2732
Thomas BoeleA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0001-9322-7762
Simon B DuckettDepartment of Chemistry, University of York, York, UK.ORCID 0000-0002-9788-6615
Boyd M GoodsonSchool of Chemical & Biomolecular Sciences, Southern Illinois University, Carbondale, IL, USA.ORCID 0000-0001-6079-5077
Matthew S RosenA. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.ORCID 0000-0002-7194-002X
Eduard Y ChekmenevIntegrative Biosciences, Department of Chemistry, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-8745-8801
Hong YuanDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carlos DedesmaVizma Life Sciences, Chapel Hill, NC, 27514, USA.
Terence GadeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8783-0661
Stephen KadlecekDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, NC, USA.
Patrick TomHonVizma Life Sciences, Chapel Hill, NC, 27514, USA.ORCID 0000-0003-3202-9812

Funding

North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Plug-and-play Hyperpolarized MRI of Metabolism on Clinical ScannersR01EB034197 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Eduard Chekmenev, Matthew Scot Rosen · 2024 to 2026
$1.8M
Automated microfluidic hyperpolarization reactor for neurometabolic imagingR43MH129007 · NIMH · VIZMA LIFE SCIENCES, INC. · PI DEDESMA, CARLOS, TOMHON, PATRICK · 2022 to 2023
$977k
Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
Rapid low-cost production of contrast agents for metabolic imagingR21EB033872 · NIBIB · WAYNE STATE UNIVERSITY · PI CHEKMENEV, EDUARD · 2023 to 2024
$415k
Non-invasive molecular imaging tool for rapid, longitudinal assessment of localized metabolic disruptions in animal research and careR43OD034168 · OD · VIZMA LIFE SCIENCES, INC. · PI DEDESMA, CARLOS, THEIS, THOMAS · 2023 to 2023
$275k
Australian NHMRC Investigator 1194004National Institutes of Health NCATS UM1TR004406NCATS NIH HHS UM1 TR004406NIBIB NIH HHS R01 EB029829NIBIB NIH HHS R01 EB034197NIBIB NIH HHS R21 EB033872NIH HHS R43MH129007NIH HHS R43 OD034168NIMH NIH HHS R43 MH129007NSF CHE-2404387NSF CHE-2404388UK government's Horizon Europe funding guarantee EP/X023672/1UK Research and Innovation (UKRI)
6 · The paper itself

Abstract

Hyperpolarized (HP) MRI using [1-

Indexed as

Magnetic Resonance ImagingPyruvic AcidAnimalsCarbon IsotopesCarcinoma, HepatocellularHumansLiver NeoplasmsSolventsCarbon-13Carbon IsotopesPyruvic AcidSolventsHyperpolarizationMagnetic resonance imaging (MRI)Metabolic imagingParahydrogenPyruvate

Identifiers

PMID40268681
PMCPMC12377446

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.