Evidence map›Paper›PMID 40268411›Full record

ArticleFukushima journal of medical science2025

Prognosis of pregnant women with epilepsy and their neonates: a case series study.

Hitoshi Masamoto, Momoko Murata, Miya Ooshiro, Morihiko Inamine, Tadakazu Uesato, Hiraku Nagasaki, Masato Hiyane, Masaya Nakamoto, Kouhei Hironaka

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In one paragraph

Article in Fukushima journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hitoshi MasamotoDepartment of Obstetrics and Gynecology, Japanese Red Cross Okinawa Hospital.
Momoko MurataDepartment of Obstetrics and Gynecology, Japanese Red Cross Okinawa Hospital.
Miya OoshiroDepartment of Obstetrics and Gynecology, Japanese Red Cross Okinawa Hospital.
Morihiko InamineDepartment of Obstetrics and Gynecology, Japanese Red Cross Okinawa Hospital.
Tadakazu UesatoDepartment of Obstetrics and Gynecology, Japanese Red Cross Okinawa Hospital.
Hiraku NagasakiDepartment of Pediatrics, Japanese Red Cross Okinawa Hospital.
Masato HiyaneDepartment of Pediatrics, Japanese Red Cross Okinawa Hospital.
Masaya NakamotoDepartment of Pediatrics, Japanese Red Cross Okinawa Hospital.
Kouhei HironakaDepartment of Neurosurgery, Japanese Red Cross Okinawa Hospital.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the outcomes of pregnant women with epilepsy and their neonates, including the incidence of neonatal withdrawal syndrome.

methodsIn total, 26 pregnancies in 20 mothers with epilepsy were retrospectively examined for the presence of complications before and during pregnancy, number of antiseizure medications taken, gestational weeks at delivery, mode of delivery, number of seizure episodes during pregnancy and postpartum, neonatal birth weight, Apgar score, pH of the umbilical cord arterial blood, neonatal abnormalities, and neonatal withdrawal syndrome.

resultsOverall, 25 of the 26 pregnancies resulted in live births, with 4 cases undergoing premature deliveries.　Ten cases underwent cesarean section, with only one case undergoing cesarean section due to the fear of experiencing seizure during vaginal delivery.　During pregnancy, two cases experienced one seizure episode.　The rate of small for gestational age was 8.0%, and three neonates had congenital abnormalities.　Withdrawal symptoms were observed in 75% of the neonates, but none of them obtained ≥8 points in the withdrawal checklist, the threshold for pharmacotherapy.

conclusionsFor women with epilepsy who receive medical management and establish good control prior to pregnancy, child birth may be relatively safe, with a low rate of neonatal withdrawal syndrome requiring pharmacotherapy.

Indexed as

EpilepsyPregnancy ComplicationsAdultAnticonvulsantsFemaleHumansInfant, NewbornNeonatal Abstinence SyndromePregnancyPregnancy OutcomePrognosisRetrospective StudiesAnticonvulsantsepilepsymaternal outcomeneonatal outcomeneonatal withdrawal syndromepregnancy

Identifiers

PMID40268411
PMCPMC12591386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.