ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2026
Transdiagnostic Neurobiology of Social Cognition and Individual Variability as Measured by Fractional Amplitude of Low-Frequency Fluctuation in Autism and Schizophrenia Spectrum Disorders.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mentalizing impairments across 11 psychiatric conditions: A transdiagnostic systematic review and network meta-analysis of tasks with static illustrations.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations With Cognition and Functioning.Human brain mapping · 2026Article
- Integrative social cognition remediation with social skills training for adults: PICSIS - pilot study in autism and schizophrenia.Frontiers in psychiatry · 2025Article
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Abstract
backgroundFractional amplitude of low-frequency fluctuation (fALFF) is a validated measure of resting-state spontaneous brain activity. Previous fALFF findings in autism and schizophrenia spectrum disorders (SSDs) have been highly heterogeneous. We aimed to use fALFF in a large sample of typically developing control participants (TDCs), autistic participants, and participants with SSDs to explore group differences and relationships with interindividual variability of fALFF maps and social cognition.
methodsfALFF from 495 participants (185 TDCs, 68 with autism, and 242 with SSDs) was computed using functional magnetic resonance imaging as signal power within 2 frequency bands (i.e., slow-4 and slow-5), normalized by the power in the remaining frequency spectrum. Permutation analysis of linear models was used to investigate the relationship of fALFF with diagnostic groups, higher-level social cognition, and lower-level social cognition. Each participant's average distance of fALFF map to all others was defined as a variability score, with higher scores indicating less typical maps.
resultsLower fALFF in the visual and higher fALFF in the frontal regions were found in both participants with SSDs and autistic participants compared with TDCs. Limited differences were observed between autistic participants and participants with SSDs in the cuneus regions only. Associations between slow-4 fALFF and higher-level social cognitive scores across the whole sample were observed in the lateral occipitotemporal and temporoparietal junction. Individual variability within the autism and SSD groups was also significantly higher than within the TDC group.
conclusionsSimilar patterns of fALFF and individual variability in autism and SSDs suggest some common neurobiological features across these related heterogeneous conditions.
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