Trial reportAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2025
Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study.
Trial report in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Plasma Biomarkers of Kidney Tubule Health during Ambulatory AKI and Kidney Function Recovery in SPRINT.Clinical journal of the American Society of Nephrology : CJASN · 2026Trial
- Relation of Urine Cell-Free Mitochondrial DNA Quantified by Droplet Digital Polymerase Chain Reaction With Tubule Injury, Dysfunction, and Ambulatory Acute Kidney Injury.Kidney medicine · 2026Article
- Mendelian Randomization Analysis of Psoriasis and Multiparameter Renal Function Trajectories.Endocrine, metabolic & immune disorders drug targets · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
RATIONALE &
objectiveSerum creatinine elevations in the ambulatory setting frequently occur during antihypertensive treatment and complicate clinical management, but few tools are available to distinguish whether kidney function will recover in this setting. This study evaluated whether urine biomarkers of glomerular and tubular health are associated with subsequent recovery of estimated glomerular filtration rate (eGFR) after acute kidney injury (AKI) has occurred in the ambulatory setting during blood pressure (BP) treatment. STUDY
designLongitudinal analysis of clinical trial participants. SETTING &
participants652 participants in SPRINT (the Systolic Blood Pressure Intervention Trial) in whom AKI developed in the ambulatory setting, defined as an increase in serum creatinine of≥0.3mg/dL from baseline detected at the 1-year or 2-year study visit. EXPOSURE: Eight urine biomarkers indexed to urine creatinine (Cr) measured at baseline and at the study visit when ambulatory AKI was detected. OUTCOME: <50% recovery in eGFR ("nonrecovery") at 12 months. ANALYTICAL APPROACH: Multivariable logistic regression models, stratified by randomization arm, to evaluate biomarker associations with the odds of nonrecovery of eGFR.
resultsMean age was 70±10 years; eGFRs were 62±25mL/min/1.73m LIMITATIONS: Persons with diabetes and proteinuria>1g/d were excluded.
conclusionsAmong adults enrolled in a BP treatment trial who experienced ambulatory AKI, urine biomarkers reflecting glomerular injury and tubular dysfunction may help to distinguish whether kidney function will subsequently recover. PLAIN-LANGUAGE SUMMARY: Increases in serum creatinine concentration can occur when treating hypertension and complicate clinical management, but there are few tools available to distinguish whether an individual's kidney function will subsequently recover. In this study, we investigated the association of kidney biomarkers measured in the urine with subsequent kidney function among individuals in the outpatient setting in whom an increase in serum creatinine occurs. We found that biomarkers reflecting worse glomerular injury and tubular dysfunction are associated with the risk of an individual's kidney function not recovering. These results suggest that a broader assessment of kidney health when serum creatinine increases in the outpatient setting may help distinguish subsequent trajectories in kidney function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.