Evidence map›Paper›PMID 40268169›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025

Myocardial native T1 and extracellular volume measurements at 5T: Feasibility study and initial experience.

Yubo Guo, Lu Lin, Keting Xu, Shihai Zhao, Gan Sun, Yuyan Chen, Ke Xue, Yuxin Yang, Shuo Chen, Yan Zhang and 2 more

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Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Reference ranges for myocardial native T1, T2, and extracellular volume at 5.0T cardiac magnetic resonance imaging in healthy adults.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026
    Article
  4. Review
  5. Recent advances in biomarkers for cardiac fibrosis.Frontiers in cardiovascular medicine · 2026
    Review
  6. Accurate myocardial T1 mapping at 5T using an improved modified Look-Locker inversion recovery method: A validation study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yubo GuoDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Lu LinDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Keting XuDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Shihai ZhaoDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Gan SunTheranostics and Translational Research Center, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yuyan ChenUnited Imaging Research Institute of Intelligent Imaging, Beijing, China.
Ke XueUnited Imaging Research Institute of Intelligent Imaging, Beijing, China.
Yuxin YangUnited Imaging Research Institute of Intelligent Imaging, Beijing, China.
Shuo ChenUnited Imaging Research Institute of Intelligent Imaging, Beijing, China.
Yan ZhangUnited Imaging Research Institute of Intelligent Imaging, Beijing, China.
Yanjie ZhuPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. Electronic address: yj.zhu@siat.ac.cn.
Yining WangDepartment of Radiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. Electronic address: wangyining@pumch.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT1 mapping is a robust and highly reproducible technique for quantitative assessment of cardiomyopathy. The aim of this study is to investigate the feasibility of 5T myocardial T1 mapping and to establish preliminary reference values for myocardial T1 at 5T.

methodsTwenty-eight healthy volunteers (median age, 42 [interquartile range (IQR): 29-54] years; 14 male) and 11 patients (median age, 44 [IQR: 34-51] years; 7 male) underwent cardiovascular magnetic resonance at 5T. T1 mapping was acquired using a motion-corrected modified Look-Locker inversion recovery sequence [5(3)3 scheme for pre-contrast, (4(1)3(1)2) scheme for post-contrast] in three short-axis planes (base, middle, and apex). T1 values were quantified per segment, per slice, and globally.

resultsHealthy volunteers had a mean global native T1 value of 1506.2 ± 41.7 ms, with T1 values decreasing progressively from the base to the apex slice (P = 0.08). Significantly higher T1 values were revealed in the septum compared to the non-septal myocardium (1540.1 ± 69.3 vs 1477.6 ± 93.7, P < 0.001). No statistically significant gender- and age-related differences were observed in native T1 values (both, P > 0.05). Within the spectrum of cardiac pathologies analyzed in this study, patients exhibited higher native T1 values (1638.7 ± 108.6 ms vs 1506.2 ± 41.7 ms, P < 0.001) and higher extracellular volume fraction (37.5% ± 5.5% vs 29.5% ± 2.1%, P = 0.074) compared to healthy volunteers, late gadolinium enhancement (LGE)-positive segments exhibited significantly higher T1 values than LGE-negative segments (1685.2 ± 144.1 vs 1582.6 ± 88.7, P < 0.001). There was excellent intra-scanner test-retest, intra-observer, and inter-observer reproducibility for measurement of native T1.

conclusionThe present study demonstrated the feasibility of T1 mapping quantification at 5T and presented mean native T1 values in healthy human myocardium at this field strength, which can be used as reference values specific for this magnetic resonance setting.

Indexed as

CardiomyopathiesMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMyocardiumAdultCase-Control StudiesContrast MediaFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedObserver VariationPredictive Value of TestsReference ValuesContrast MediaECVNative T1Reference valuesT1 mapping

Identifiers

PMID40268169
PMCPMC12182820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.