ArticleJournal of dentistry2025
A dual action approach of B-type proanthocyanidins for silencing enzymatic activity and sealing natural caries-affected dentin-resin interfaces.
Article in Journal of dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Dentin Biomodification on the Survival of Resin Composite Restorations: An Umbrella Review.International dental journal · 2026Pooled it
- Long-term nano-dynamic mechanical analysis and micro-permeability of adhesive interface components using four AB-type proanthocyanidin neutral primers.Journal of dentistry · 2026Article
- Exploring the extraction, antioxidant activities and its stabilities of peanut skins crude proanthocyanidins extract.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectivesThis study explored the potential of dimeric and trimeric B-type proanthocyanidins (PACs) to silence dentin-associated enzymes as well as enhance sealing at the hybrid layer and in the underlying dentin of dentin-resin interfaces in both sound and natural caries-affected dentin (NCAD).
methodsIntervention materials were chemically standardized formulations of B-type dimeric (B) and trimeric (BB) PACs from Theobroma cacao (TC), prepared using the DESIGNER approach (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources). Human teeth were divided into two groups based on dentin substrate (sound dentin vs. NCAD) and three experimental groups (10 % TC-B primer, 10 % TC-BB primer, and HEPES primer as control). Bonding procedures utilized the etch-and-rinse technique. Specimens were prepared for interfacial in-situ zymography and interfacial micro-permeability assay and evaluated under a fluorescent microscope. Fluorescence intensities were calculated and analyzed using three-way ANOVA and post-hoc tests (α = 0.05).
resultsNCAD at the dentin-resin interface showed higher enzymatic activity when compared to sound dentin (p < 0.001). Enzymatic activity was significantly higher in sound (p < 0.001) and NCAD (p < 0.001) control groups relative to PAC-treated groups, with the latter exhibiting a substantial enzyme-silencing effect. No significant differences were observed between TC-B and T-BB groups (p = 1.0). Interfacial micro-permeability showed a similar trend, with the DESIGNER-treated groups exhibiting a profound sealing in NCAD, reaching depths up to 60 µm.
conclusionsBoth B-type PAC-DESIGNERs are remarkably effective at reducing the enzymatic activity and sealing the resin-dentin interface as well as the underlying sound and NCAD dentin. CLINICAL SIGNIFICANCE: This study highlights the relevance of developing functional biomaterials capable of optimizing the adhesion of the dentin-resin interface while preserving the collagen matrix through effective enzymatic inhibition and improved sealing ability, particularly when bonding to caries-affected dentin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.