Evidence map›Paper›PMID 40268039›Full record

ArticleBrain research2025

A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons.

Kathleen R Louis-Gray, Joseph A Beatty, Charles L Cox

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kathleen R Louis-GrayDepartment of Physiology, Neuroscience Program, Michigan State University, East Lansing, MI 48824, United States.
Joseph A BeattyDepartment of Physiology, Neuroscience Program, Michigan State University, East Lansing, MI 48824, United States.
Charles L CoxDepartment of Physiology, Neuroscience Program, Michigan State University, East Lansing, MI 48824, United States. Electronic address: coxclee@msu.edu.

Funding

Modulation of Subcortical Visual Information ProcessingR01EY014024 · NEI · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI COX, CHARLES LEROY · 2003 to 2012
$2.6M
Synaptic Phenotype, Development, and Plasticity in the Fragile X MouseR01MH085324 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI COX, CHARLES LEROY · 2010 to 2015
$2.1M
Modulation of Subcortical Visual Information ProcessingR56EY014024 · NEI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI COX, CHARLES LEROY · 2009 to 2009
$384k
NEI NIH HHS R01 EY014024NEI NIH HHS R56 EY014024NIMH NIH HHS R01 MH085324
6 · The paper itself

Abstract

Information transfer through the thalamus is a dynamic process, which can be influenced by multiple factors within the thalamocortical circuit. Activity-dependent changes in neuronal excitability and synaptic efficacy can impact both short- and long-term processing through the thalamocortical circuit. In these experiments, we investigate the mechanism of a novel form of post-tetanic synaptic plasticity, induced by tetanic stimulation of excitatory afferents onto thalamocortical neurons. We show that tetanic activation of excitatory afferents produces a short-lasting (10-15 min) facilitation of excitatory postsynaptic currents in ventrobasal thalamocortical neurons. This potentiation is mediated by a calcium-dependent, presynaptic mechanism. This potentiation is partly due to the activation of adenylyl cyclase and involves alteration in the hyperpolarization-activated mixed cation current, I

Indexed as

Cerebral CortexNeuronal PlasticityNeuronsThalamusAdenylyl CyclasesAnimalsElectric StimulationExcitatory Postsynaptic PotentialsNeural PathwaysPatch-Clamp TechniquesRatsSynaptic TransmissionAdenylyl CyclasesCorticothalamic afferentPost-tetanic synaptic plasticityThalamocortical circuitThalamusVentrobasal nucleus

Identifiers

PMID40268039
PMCPMC12109712

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.