Evidence map›Paper›PMID 40267916›Full record

ArticleCurrent biology : CB2025

Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning.

Gabriela C Lopez, Louis D Van Camp, Ryan F Kovaleski, Michael D Schaid, Venus N Sherathiya, Julia M Cox, Talia N Lerner

Abstract read
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  11. Article
  12. Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Review
  14. Untangling dopamine and glutamate in the ventral tegmental area.bioRxiv : the preprint server for biology · 2025
    Article
  15. How Dopamine Enables Learning from Aversion.Current opinion in behavioral sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabriela C LopezDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Northwestern University Interdepartmental Neuroscience Program (NUIN), Evanston, IL 60208, USA.
Louis D Van CampDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Ryan F KovaleskiDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Michael D SchaidDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Venus N SherathiyaDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Julia M CoxDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Talia N LernerDepartment of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Northwestern University Interdepartmental Neuroscience Program (NUIN), Evanston, IL 60208, USA. Electronic address: talia.lerner@northwestern.edu.

Funding

Rodent Behavior CoreP50DA044121 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI APKARIAN, APKAR VANIA · 2018 to 2022
$9.0M
TRAINING IN METABOLISM, DIABETES AND ENDOCRINOLOGYT32DK007169 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Joseph Bass · 1988 to 2026
$6.6M
How Early-Life Experiences Create Individual Variation in Dopamine Circuit Architecture: Understanding Risk for Psychiatric DiseaseDP2MH122401 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LERNER, TALIA NEWCOMBE · 2019 to 2022
$2.5M
Plasticity and Function of Dopamine Circuits Regulating the Transition to HabitR01MH125885 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jones G Parker · 2023 to 2026
$2.0M
Contributions of Parallel Nigrostriatal Dopamine Circuits to Reward Learning and Habit FormationR00MH109569 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LERNER, TALIA NEWCOMBE · 2017 to 2019
$874k
A role for hypothalamic dopamine in predicting homeostatic needF32DK135313 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHAID, MICHAEL · 2023 to 2024
$130k
Chronic Pain Modulation of Mesolimbic Dopamine Signaling for Natural and Opiate RewardsF31DA056200 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LOPEZ, GABRIELA CAROLINA · 2022 to 2024
$129k
NIDA NIH HHS F31 DA056200NIDA NIH HHS P50 DA044121NIDDK NIH HHS F32 DK135313NIDDK NIH HHS T32 DK007169NIMH NIH HHS DP2 MH122401NIMH NIH HHS R00 MH109569NIMH NIH HHS R01 MH125885
6 · The paper itself

Abstract

Avoidance learning-learning to avoid bad outcomes-is an essential survival behavior. Dopamine signals are widely observed in response to aversive stimuli, indicating they could play a role in learning about how to avoid these stimuli.

Indexed as

Avoidance LearningDopamineNucleus AccumbensAnimalsCuesMaleMiceMice, Inbred C57BLDopaminedopamine heterogeneityinstrumental learningnegative reinforcementnucleus accumbensstriatumventral tegmental area

Identifiers

PMID40267916
PMCPMC12092177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.