ArticleCell reports. Medicine2025
CD47-blocking antibody confers metabolic benefits against obesity.
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Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure.Experimental & molecular medicine · 2026Article
- Mechanisms and therapeutic potential of AMPK signaling pathway in the regulation of lipid metabolism.Molecular biology reports · 2026Review
- CD47 Promotes, While Exposure to Apoptotic Cells Destroys the Fusion Program of Differentiating Myoblasts.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Impact of Obesity on Immunity to the Influenza Virus: Gut Microbiota, Mechanisms, and Novel Therapeutic Strategies.Diseases (Basel, Switzerland) · 2025Review
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Authors and funding
25 authors.
Yajuan SuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China; Tsingtao Advanced Research Institute, Tongji University, Qingdao 266071, China.
Jingyu SunInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Xiaobo LiTsingtao Advanced Research Institute, Tongji University, Qingdao 266071, China.
Feier HuangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Yunhui KongInstitute of Modern Biology, Nanjing University, Nanjing 210023, China.
Zian ChenInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Jingzhi ZhangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Duran QinInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Xiangyi ChenInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Zhaoyue WangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Yu PeiDepartment of Physiology and Pharmacology, Karolinska Institute, 17177 Solna, Sweden.
Mengting GongInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Kaijiang YangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Minglu XuInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Yu DongInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Qing HeInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Zhen-Ning ZhangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Zhejin ShengInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Qiaolin DengDepartment of Physiology and Pharmacology, Karolinska Institute, 17177 Solna, Sweden.
Hong WangInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China.
Gaowei WangInstitute of Modern Biology, Nanjing University, Nanjing 210023, China.
Ping HuColorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai TenthPeople's Hospital Affiliated to Tongji University, Shanghai 200031, China; Guangzhou Laboratory, No. 9 XingDaoHuan Road, Guanghzou International Bio lsland, Guangzhou 510005, China.
Rongrong LeInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China. Electronic address: lerongrong@tongji.edu.cn.
Shaorong GaoInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China; Tsingtao Advanced Research Institute, Tongji University, Qingdao 266071, China. Electronic address: gaoshaorong@tongji.edu.cn.
Weida LiInstitute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Sports and Health Research Center, Tongji University Department of Physical Education, Tongji University, Shanghai 200092, China; Tsingtao Advanced Research Institute, Tongji University, Qingdao 266071, China. Electronic address: weidali@tongji.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD47-blocking antibody is a well-known potential antibody drug for tumor immunotherapy. However, it is unclear whether CD47-blocking antibody can protect against metabolic disorders. We report that high-fat diet (HFD)-induced obesity increases CD47 expression, while exercise downregulates it in skeletal muscle. Administration of CD47-blocking antibody in mice prevents HFD-induced weight gain and glucose intolerance, enhances exercise capacity, and improves body composition and skeletal muscle mitochondrial function. Mechanistically, the protective effects conferred by CD47-blocking antibody are mediated through activation of AMP-activated protein kinase (AMPK) in skeletal muscle. Consistently, muscle-specific CD47-knockout mice show similar metabolic improvements, indicating a direct muscle-specific role of CD47 in regulating AMPK activation in vivo. Furthermore, the CD47-blocking antibody reduces the phosphorylation of heat shock protein 90α (HSP90α) to activate AMPK in skeletal muscle. In conclusion, CD47-blocking antibody confers metabolic benefits by activating the AMPK pathway in skeletal muscle.
Indexed as
Antibodies, BlockingCD47 AntigenObesityAMP-Activated Protein KinasesAnimalsDiet, High-FatHSP90 Heat-Shock ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, SkeletalPhosphorylationPhysical Conditioning, AnimalAMP-Activated Protein KinasesAntibodies, BlockingCD47 AntigenHSP90 Heat-Shock ProteinsAMPKCD47-blocking antibodymetabolic disordersskeletal muscle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.