Evidence map›Paper›PMID 40267909›Full record

ArticleCell reports2025

PERK-dependent reciprocal crosstalk between ER and non-centrosomal microtubules coordinates ER architecture and cell shape.

Miguel Sánchez-Álvarez, Fidel Nicolás Lolo, Heba Sailem, Giulio Fulgoni, Patricia Pascual-Vargas, Lucía Agüera, Mauro Catalá-Montoro, Mar Arias-García, Juan Antonio López, Jesús Vázquez and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miguel Sánchez-ÁlvarezDynamical Cell Systems Team, Division of Cancer Biology, The Institute of Cancer Research-Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK; Cell Compartmentalization, Homeostasis and Inflammation Team, Department of Metabolic and Inflammatory Diseases, Instituto de Investigaciones Biomédicas "Sols-Morreale", CSIC-UAM, CP 28029 Madrid, Spain. Electronic address: msalvarez@iib.csic.es.
Fidel Nicolás LoloMechanoadaptation and Caveolae Biology Laboratory, Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/Melchor Fernandez Almagro, 3, CP 28029 Madrid, Spain.
Heba SailemDynamical Cell Systems Team, Division of Cancer Biology, The Institute of Cancer Research-Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.
Giulio FulgoniCell Compartmentalization, Homeostasis and Inflammation Team, Department of Metabolic and Inflammatory Diseases, Instituto de Investigaciones Biomédicas "Sols-Morreale", CSIC-UAM, CP 28029 Madrid, Spain.
Patricia Pascual-VargasDynamical Cell Systems Team, Division of Cancer Biology, The Institute of Cancer Research-Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.
Lucía AgüeraCell Compartmentalization, Homeostasis and Inflammation Team, Department of Metabolic and Inflammatory Diseases, Instituto de Investigaciones Biomédicas "Sols-Morreale", CSIC-UAM, CP 28029 Madrid, Spain.
Mauro Catalá-MontoroMechanoadaptation and Caveolae Biology Laboratory, Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/Melchor Fernandez Almagro, 3, CP 28029 Madrid, Spain.
Mar Arias-GarcíaDynamical Cell Systems Team, Division of Cancer Biology, The Institute of Cancer Research-Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK.
Juan Antonio LópezProteomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/Melchor Fernandez Almagro, 3, CP 28029 Madrid, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Jesús VázquezCardiovascular Proteomics Lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/Melchor Fernandez Almagro, 3, CP 28029 Madrid, Spain; CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.
Miguel Ángel Del PozoMechanoadaptation and Caveolae Biology Laboratory, Area of Cell and Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), c/Melchor Fernandez Almagro, 3, CP 28029 Madrid, Spain.
Chris BakalDynamical Cell Systems Team, Division of Cancer Biology, The Institute of Cancer Research-Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK. Electronic address: cbakal@icr.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The architecture of the endoplasmic reticulum (ER) is a key determinant of its function. Its dynamics are linked to those of the cytoskeleton, but our understanding of how this coordination occurs and what its functional relevance is, limited. Here, we report that the unfolded protein response (UPR

Indexed as

Cell ShapeCentrosomeeIF-2 KinaseEndoplasmic ReticulumMicrotubulesAnimalsEukaryotic Initiation Factor-2HumansMicePhosphorylationUnfolded Protein ResponseeIF-2 KinaseEukaryotic Initiation Factor-2cell polarityCP: Cell biologyEIF2AK3/PERKendoplasmic reticulumintegrated stress responsenon-centrosomal microtubules

Identifiers

PMID40267909
PMCPMC12548782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.