Evidence map›Paper›PMID 40267743›Full record

ArticleMultiple sclerosis and related disorders2025

Avoidance behavior mediates the relationship between concern about falling and impaired mobility in multiple sclerosis.

Taylor N Takla, Patrick G Monaghan, Ana M Daugherty, Nora E Fritz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis and related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Taylor N TaklaNeuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit MI, USA; Translational Neuroscience Program, Wayne State University, Detroit MI, USA. Electronic address: taylortakla@wayne.edu.
Patrick G MonaghanNeuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit MI, USA; Department of Health Care Sciences, Wayne State University, Detroit MI, USA.
Ana M DaughertyTranslational Neuroscience Program, Wayne State University, Detroit MI, USA; Department of Psychology, Wayne State University, Detroit, MI, USA; Institute of Gerontology, Wayne State University, Detroit, MI, USA.
Nora E FritzNeuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit MI, USA; Translational Neuroscience Program, Wayne State University, Detroit MI, USA; Department of Health Care Sciences, Wayne State University, Detroit MI, USA; Department of Neurology, Wayne State University, Detroit, MI, USA.

Funding

Backward Walking as a Novel Fall Prediction Tool for Multiple SclerosisR21HD106133 · NICHD · WAYNE STATE UNIVERSITY · PI FRITZ, NORA E. · 2022 to 2023
$412k
Investigating Fear of Falling in Multiple Sclerosis: An Interplay of Neural, Motor, Cognitive, and Psychological FactorsF31HD116491 · NICHD · WAYNE STATE UNIVERSITY · PI TAKLA, TAYLOR · 2024 to 2025
$97k
NICHD NIH HHS F31 HD116491NICHD NIH HHS R21 HD106133
6 · The paper itself

Abstract

backgroundConcern about falling (CAF) is common in multiple sclerosis (MS) and affects mobility and activity, even without a history of a falls.

objectivesThis study aimed to assess how avoidance behavior contributes to CAF-related mobility impairments and whether this association is consistent for fallers and non-fallers.

methodsParticipants completed questionnaires regarding CAF, avoidance behavior, and self-reported walking impairment, and laboratory walking and balance assessments. Applied structural equation modeling tested a hypothesized mediation model in which the relationship between CAF and mobility impairments would be partially mediated by avoidance behavior. Walking and balance assessments were used to construct a mobility latent factor. The model was subsequently stratified by fallers and non-fallers.

resultsParticipants included 52 individuals with MS. 46.96 % of the significant total effect of CAF on mobility was accounted for by avoidance behaviors. No significant differences were found between fallers and non-fallers, suggesting a consistent mediation effect across both groups.

conclusionsOur findings underscore the role of avoidance behavior in partially accounting for the effects of CAF on mobility deficits among persons with MS. This effect was statistically equivalent across fall status, highlighting the pervasive impact of avoidance behavior on mobility impairments in MS.

Indexed as

Accidental FallsAvoidance LearningMobility LimitationMultiple SclerosisPostural BalanceAdultFemaleHumansMaleMiddle AgedWalkingAvoidance behaviorConcern about fallingFallsMobility impairmentsMultiple sclerosis

Identifiers

PMID40267743
PMCPMC12167679

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.