Evidence map›Paper›PMID 40267387›Full record

ArticleJCO precision oncology2025

Prognostic Significance of Germline

Alexander T Nelson, Dave Watson, Kenneth S Chen, Damon R Olson, Jennifer N Stall, Kyle M Devins, Robert H Young, Junne Kamihara, Paige H R Mallinger, Jung Kim and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCO precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Cancers · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alexander T NelsonInternational Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN.ORCID 0000-0002-1611-4577
Dave WatsonResearch Institute, Children's Minnesota, Minneapolis, MN.ORCID 0000-0002-2749-6136
Kenneth S ChenDepartment of Pediatrics, UT Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-2304-4631
Damon R OlsonDepartment of Pathology and Laboratory Medicine, Children's Minnesota, Minneapolis, MN.ORCID 0000-0001-9727-569X
Jennifer N StallHospital Pathology Associates, Minneapolis, MN.
Kyle M DevinsJames Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-8097-2437
Robert H YoungJames Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Junne KamiharaPediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.ORCID 0000-0002-2852-7387
Paige H R MallingerInternational Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN.ORCID 0009-0001-6294-1733
Jung KimClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0001-6274-2841
Jessica N HattonClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0003-2104-171X
Yoav H MessingerInternational Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN.ORCID 0000-0001-7990-1802
A Lindsay FrazierPediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA.ORCID 0000-0003-4748-8552
Douglas R StewartClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.ORCID 0000-0001-8193-1488
Dominik T SchneiderClinic of Pediatrics, Municipal Hospital Dortmund, University Witten/Herdecke, Dortmund, Germany.
Anne K HarrisInternational Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN.ORCID 0000-0002-3371-3096
Louis P DehnerDepartment of Pathology and Immunology, Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO.ORCID 0000-0002-2007-5638
D Ashley HillDepartment of Pathology and Immunology, Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO.ORCID 0000-0003-1067-3922
Kris Ann P SchultzInternational Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN.ORCID 0000-0002-1788-5832

Funding

DICER1 and the Pleuropulmonary Blastoma Family Cancer SyndromeR01CA143167 · NCI · CHILDREN'S RESEARCH INSTITUTE · PI HILL, DANA ASHLEY · 2010 to 2020
$3.7M
Detecting DICER1: A global partnership to cure pediatric lung cancerR37CA244940 · NCI · CHILDREN'S HOSPITALS AND CLINICS · PI Kris Ann Pinekenstein Schultz · 2020 to 2026
$2.4M
NCI NIH HHS R01 CA143167NCI NIH HHS R37 CA244940
6 · The paper itself

Abstract

purposeSertoli-Leydig cell tumors (SLCTs) are rare sex cord-stromal tumors, representing <0.5% of all ovarian tumors. We analyze the role of germline

methodsPatients with SLCT were enrolled in the International Pleuropulmonary Blastoma/

resultsOf 162 patients with SLCT, 60% had a germline

conclusionThis cohort study of patients with SLCT demonstrated that those with germline

Indexed as

DEAD-box RNA HelicasesOvarian NeoplasmsRibonuclease IIISertoli-Leydig Cell TumorAdolescentAdultFemaleGerm-Line MutationHumansMiddle AgedPrognosisYoung AdultDEAD-box RNA HelicasesDICER1 protein, humanRibonuclease III

Identifiers

PMID40267387
PMCPMC12781502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.