Evidence map›Paper›PMID 40267318›Full record

ArticleJournal of medicinal chemistry2025

Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT

Joanna Sniecikowska, Monika Gluch-Lutwin, Adam Bucki, Beata Gryzlo, Krzysztof Wieckowski, Justyna Godyn, Anna Wieckowska, Agata Siwek, Magdalena Jastrzebska-Wiesek, Anna Partyka and 4 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Joanna SniecikowskaJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0002-5296-7964
Monika Gluch-LutwinJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.
Adam BuckiJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0003-0451-9814
Beata GryzloJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0002-5165-5045
Krzysztof WieckowskiJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0002-5234-9103
Justyna GodynJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0002-0295-2772
Anna WieckowskaJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0003-2549-170X
Agata SiwekJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.
Magdalena Jastrzebska-WiesekJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0002-5388-1214
Anna PartykaJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.
Agnieszka CiosJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.
Anna WesolowskaJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.
Adrian Newman-TancrediNeurolixis SAS, Labruguière, Castres 81290, France.ORCID 0000-0002-2923-5714
Marcin KolaczkowskiJagiellonian University Medical College, 9 Medyczna Street, Kraków 30-688, Poland.ORCID 0000-0001-8402-1121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the discovery of NLX-266 (

Indexed as

Antidepressive AgentsAntiparkinson AgentsReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor AgonistsAdministration, OralAnimalsCatalepsyDrug DiscoveryHumansMaleMiceRatsRats, Sprague-DawleyStructure-Activity RelationshipAntidepressive AgentsAntiparkinson AgentsReceptor, Serotonin, 5-HT1ASerotonin 5-HT1 Receptor Agonists

Identifiers

PMID40267318
PMCPMC12067441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.