ReviewChembiochem : a European journal of chemical biology2025
Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans.
Review in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Advances in chemoenzymatic synthesis of glycosaminoglycans and proteoglycans.Current opinion in chemical biology · 2026Review
- Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities.Angewandte Chemie (International ed. in English) · 2026Article
- Design of Glycosyltransferase Inhibitors: Targeting the Biosynthesis of Glycosaminoglycans by Phosphonate-Xyloside.ACS omega · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Proteoglycans (PGs) play roles in many important biological events, including growth factor signaling, wound repair, blood coagulation, brain development, and neural stem cell migration. As the glycosaminoglycan chain of PGs is attached to the core protein through a tetrasaccharide linkage region, it is important to decipher the intricate control of the multitude of enzymes engaged in biosynthesis of the linkage region. During the past two decades, significant advances have been achieved in our understanding of the identity and interactions of these enzymes as well as the control of their activities. Furthermore, the knowledge gained on biosynthesis of the linkage region has enabled the synthesis of structurally well-defined proteoglycan-associated glycopeptides. The expression, activity, and substrate profile of enzymes and the latest development of chemoenzymatic synthesis of linkage region-bearing glycopeptides are summarized in this review.
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Registered trials
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