Evidence map›Paper›PMID 40267229›Full record

ReviewJournal of proteome research2025

Open-Source and FAIR Research Software for Proteomics.

Yasset Perez-Riverol, Wout Bittremieux, William S Noble, Lennart Martens, Aivett Bilbao, Michael R Lazear, Bjorn Grüning, Daniel S Katz, Michael J MacCoss, Chengxin Dai and 10 more

Abstract readReview
In one paragraph

Review in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yasset Perez-RiverolEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge CB10 1SD, U.K.ORCID 0000-0001-6579-6941
Wout BittremieuxDepartment of Computer Science, University of Antwerp, 2020 Antwerpen, Belgium.ORCID 0000-0002-3105-1359
William S NobleDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0001-7283-4715
Lennart MartensVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0003-4277-658X
Aivett BilbaoEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.ORCID 0000-0003-2985-8249
Michael R LazearBelharra Therapeutics, 3985 Sorrento Valley Boulevard Suite C, San Diego, California 92121, United States.ORCID 0000-0001-5313-4262
Bjorn GrüningBioinformatics Group, Department of Computer Science, Albert-Ludwigs University Freiburg, Freiburg 79110, Germany.ORCID 0000-0002-3079-6586
Daniel S KatzNational Center for Supercomputing Applications & Siebel School of Computing and Data Science & School of Information Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.ORCID 0000-0001-5934-7525
Michael J MacCossDepartment of Genome Sciences, University of Washington, 3720 15th St. NE, Seattle, Washington 98195, United States.ORCID 0000-0003-1853-0256
Chengxin DaiState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics, Beijing 102206, China.
Jimmy K EngProteomics Resource, University of Washington, Seattle, Washington 98195, United States.ORCID 0000-0001-6352-6737
Robbin BouwmeesterVIB-UGent Center for Medical Biotechnology, VIB, Ghent 9052, Belgium.ORCID 0000-0001-6807-7029
Michael R ShortreedDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0003-4626-0863
Enrique AudainInstitute of Medical Genetics, University Medicine Oldenburg, Carl von Ossietzky University, Oldenburg 26129, Germany.
Timo SachsenbergDepartment of Computer Science, Applied Bioinformatics, University of Tübingen, Tübingen 72076, Germany.ORCID 0000-0002-2833-6070
Jeroen Van GoeyInstaDeep London, London W2 1AY, U.K.
Georg WallmannProteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
Bo WenDepartment of Genome Sciences, University of Washington, Seattle, Washington 98195, United States.
Lukas KällScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm 17165, Sweden.ORCID 0000-0001-5689-9797
William E FondrieTalus Bioscience, Seattle, Washington 98122, United States.ORCID 0000-0002-1554-3716

Funding

Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI TIAN, LU · 2020 to 2024
$15.9M
Seattle Quant: A Resource for the Skyline Software EcosystemR24GM141156 · NIGMS · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 2021 to 2026
$6.7M
Quantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetesU01DK137097 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE, Michael MacCoss · 2023 to 2026
$3.4M
NIA NIH HHS U19 AG065156NIDDK NIH HHS U01 DK137097NIGMS NIH HHS R24 GM141156Wellcome Trust
6 · The paper itself

Abstract

Scientific discovery relies on innovative software as much as experimental methods, especially in proteomics, where computational tools are essential for mass spectrometer setup, data analysis, and interpretation. Since the introduction of SEQUEST, proteomics software has grown into a complex ecosystem of algorithms, predictive models, and workflows, but the field faces challenges, including the increasing complexity of mass spectrometry data, limited reproducibility due to proprietary software, and difficulties integrating with other omics disciplines. Closed-source, platform-specific tools exacerbate these issues by restricting innovation, creating inefficiencies, and imposing hidden costs on the community. Open-source software (OSS), aligned with the FAIR Principles (Findable, Accessible, Interoperable, Reusable), offers a solution by promoting transparency, reproducibility, and community-driven development, which fosters collaboration and continuous improvement. In this manuscript, we explore the role of OSS in computational proteomics, its alignment with FAIR principles, and its potential to address challenges related to licensing, distribution, and standardization. Drawing on lessons from other omics fields, we present a vision for a future where OSS and FAIR principles underpin a transparent, accessible, and innovative proteomics community.

Indexed as

ProteomicsSoftwareAlgorithmsComputational BiologyHumansMass SpectrometryReproducibility of Resultsbest practicescomputational proteomicsdata reuseFAIR principlesmass spectrometryopen dataopen sourceproteomics

Identifiers

PMID40267229
PMCPMC12053954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.