ArticleScience translational medicine2025
FcγR binding differentially contributes to protection by two human monoclonal antibodies targeting
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Article in Science translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4citing papers in PubMed
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Who cites it
4 citing papers in PubMed.
- Relevance of the antibody Fc fragment and epitope valency in protection against malaria sporozoites.EMBO reports · 2026Article
- Novel antibody cocktail therapy targeting extracellular tumor-specific mutations to treat EMT6 cell line-derived triple-negative breast cancer.Scientific reports · 2026Article
- Antibodies in tuberculosis: functional capacity as key determinant.Infection and immunity · 2026Review
- Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies.Microbiology spectrum · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Neville K KisaluVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Lais D Silva PereiraVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Jonathan D HermanRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0001-7188-4243
Mangaiarkarasi AsokanVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-9294-1833
Keenan ErnsteVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-2988-6429
Jonah MerriamVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-9203-5566
Cuiping LiuVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Megan E DeMouthVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8861-4207
Amarendra PeguVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3564-6453
Mariah LofgrenVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-7453-3262
Marlon DillonVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8670-5487
Brian BonillaVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-4067-7476
Ryan MacVicarRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0003-1552-8185
Yonatan ZurRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0002-1158-5564
Patience KiyukaVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3257-5920
Yevel Flores-GarciaMalaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0001-7230-3834
Saborni ChakrabortyInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine and Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0502-3757
Daria NikolaevaVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0009-0000-0944-8141
Rodney OgwangVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Barbara FlynnVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Joseph FrancicaVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-1336-4682
Theodore C PiersonVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3795-4348
Richard A KoupVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-3090-7282
Fidel ZavalaMalaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.ORCID 0000-0002-1414-6196
Taia T WangInstitute for Immunity, Transplantation, and Infection, Stanford University School of Medicine and Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3894-685X
Galit AlterRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.ORCID 0000-0002-9221-6735
Azza H IdrisVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-1847-5488
Robert A SederVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0003-3133-0849
Funding
Defining functional humoral correlates of immunity to guide vaccine designR01AI151178 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BATISTA, FACUNDO DAMIAN · 2021 to 2025
$4.0MSystems Antibody Immunology of the Malaria Sporozoite VaccineK08AI180370 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jonathan David Herman · 2024 to 2026
$586kBill & Melinda Gates Foundation INV-005226NIAID NIH HHS K08 AI180370NIAID NIH HHS R01 AI151178Wellcome Trust
Abstract
Antibodies mediate protection against a wide range of pathogens through binding and neutralizing the pathogen or through Fc-mediated effector functions. Human monoclonal antibodies (mAbs) CIS43LS and L9LS show high-affinity binding targeting distinct regions on the
Indexed as
Antibodies, MonoclonalPlasmodium falciparumProtozoan ProteinsReceptors, IgGAnimalsHumansMalaria, FalciparumMiceMice, Inbred C57BLPlasmodium bergheiProtein BindingAntibodies, Monoclonalcircumsporozoite protein, ProtozoanProtozoan ProteinsReceptors, IgG
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.