ArticlePLoS computational biology2025
Resource competition-driven bistability and stochastic switching amplify gene expression noise.
Article in PLoS computational biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Resource Competition and Growth Dilution Modulate Synthetic Gene Cascade Dynamics.ACS synthetic biology · 2026Article
- Coupled Perturbations of Gene Circuit Dynamics by Resource Competition and Growth Dilution.Methods in molecular biology (Clifton, N.J.) · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Although the impact of resource competition on the deterministic behavior of synthetic gene circuits has been studied, its effects on gene expression noise remain obscure. In this work, we systematically analyze the role of resource competition in noise propagation within a genetic inhibition cascade circuit. We found that resource competition amplifies gene expression noise by introducing unexpected bistability and stochastic switching between the two stable states. This emergent bistability, driven by resource competition-mediated double negative feedback, allows one gene to dominate expression while suppressing the other in a "winner-takes-all" behavior. Our findings highlight the critical role of resource competition in shaping the noise dynamics and its propagation, underscoring the importance of considering these effects when designing and controlling synthetic circuits.
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Registered trials
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