ArticlePLoS biology2025
The dorsal and ventral hippocampus contribute differentially to spatial working memory and spatial coding in the prefrontal cortex.
Article in PLoS biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Mechanical Ventilation-Associated Changes in Hippocampal Electroencephalogram: A Cross-Species Study in Humans and Rats.CNS neuroscience & therapeutics · 2026Article
- Physical restraint induces conditioned place aversion and region-specific c-Fos activation in mice.Neuroscience letters · 2026Article
- Physical restraint induces conditioned place aversion and region-specific c-Fos activation in mice.bioRxiv : the preprint server for biology · 2026Article
- Impairment of object recognition, object location and spatial working memory performance in inbred RHA vs. RLA rats.Frontiers in behavioral neuroscience · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
The hippocampus (HPC) supports spatial working memory (SWM) through its interactions with the prefrontal cortex (PFC). However, it is not clear whether and how the dorsal (dHPC) and ventral (vHPC) poles of the HPC make distinct contributions to SWM and whether they differentially influence the PFC. To address this question, we optogenetically silenced the dHPC or the vHPC while simultaneously recording from the PFC of mice performing a SWM task. We found that whereas both HPC subregions were necessary during the encoding phase of the task, only the dHPC was necessary during the choice phase. Unexpectedly, silencing of either subregion did not affect PFC neurons' ability to represent the animal's position, but did alter how it was represented. In contrast, only silencing of the vHPC affected their coding of spatial goals. These results thus reveal distinct contributions of the dorsal and ventral HPC poles to SWM and the coding of behaviorally relevant spatial information by PFC neurons.
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