Evidence map›Paper›PMID 40267138›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Elevated UDP-glucuronic acid levels mend drug resistance and stress responses via a protease and a transporter in

Sujiraphong Pharkjaksu, Hongyi Cai, Peter J Walter, Yun C Chang, Kyung J Kwon-Chung

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sujiraphong PharkjaksuMolecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Hongyi CaiClinical Mass Spectrometry Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
Peter J WalterClinical Mass Spectrometry Core, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
Yun C ChangMolecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.
Kyung J Kwon-ChungMolecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892.ORCID 0000-0003-3383-1428

Funding

HHS | NIH (NIH) Intramural Research
6 · The paper itself

Abstract

UDP-glucuronic acid (UDP-GlcUA) is a nucleotide sugar essential for various biological processes in many organisms, and its excess within the cell can disrupt cellular functions. In

Indexed as

Cryptococcus gattiiDrug Resistance, FungalFungal ProteinsMembrane Transport ProteinsPeptide HydrolasesUridine Diphosphate Glucuronic AcidAntifungal AgentsGene Expression Regulation, FungalMutationStress, PhysiologicalAntifungal AgentsFungal ProteinsMembrane Transport ProteinsPeptide HydrolasesUridine Diphosphate Glucuronic Aciddrug resistanceproteasestress responsesUDP-glucuronic acid

Identifiers

PMID40267138
PMCPMC12054807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.