Evidence map›Paper›PMID 40267137›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

B cell-derived acetylcholine mitigates skin inflammation in mice through α9 nicotinic acetylcholine receptor-mediated signaling.

Erica Foffi, Francesco Rugolo, Nisha Ramamurthy, Jillian Haight, Simone Helke, Annick You-Ten, Chantal Tobin, Soode Moghadas Jafari, Andrew J Elia, Thorsten Berger and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Ly6/uPAR Protein fromMarine drugs · 2025
    Article
  5. Article
  6. Article
  7. Topical Donepezil for Cholinergic Modulation in Chronic Wound Repair.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Erica Foffi *Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Francesco Rugolo *Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Nisha RamamurthyPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Jillian HaightPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Simone HelkePrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Annick You-TenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Chantal TobinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Soode Moghadas JafariPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Andrew J EliaTumor Immunotherapy Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Thorsten BergerPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.
Eleonora CandiIstituto Dermopatico dell'Immacolata - Istituto di Ricovero e Cura a Carattere Scientifico, Rome 00167, Italy.ORCID 0000-0001-8332-4825
Gerry MelinoDepartment of Experimental Medicine, Torvergata Onscoscience Research, University of Rome Tor Vergata, Rome 00133, Italy.ORCID 0000-0001-9428-5972
Tak W MakPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G2M9, Canada.ORCID 0000-0001-6766-861X

Funding

Canadian Government | Canadian Institutes of Health Research (CIHR) NA
6 · The paper itself

Abstract

Chronic inflammatory skin disorders are characterized by keratinocyte hyperproliferation and hyperactivation as well as immune cell infiltration. We investigated whether immune cell-derived acetylcholine (ACh) is a modulator of skin inflammation in mice. Here, we identify skin epithelial B cells as a key source of ACh that damps down inflammation. We used imiquimod (IMQ) to induce inflammatory skin disease (ISD) in mice lacking ACh production specifically in B cells (ChAT

Indexed as

AcetylcholineB-LymphocytesDermatitisReceptors, NicotinicSignal TransductionSkinAnimalsCell ProliferationCytokinesImiquimodInflammationKeratinocytesMiceMice, KnockoutAcetylcholineChrna9 protein, mouseCytokinesImiquimodReceptors, NicotinicacetylcholineB lymphocytesinflammationpsoriasisskin

Identifiers

PMID40267137
PMCPMC12054817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.