Evidence map›Paper›PMID 40267133›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Pathogen growth and virulence dynamics drive the host evolution against coinfections.

Srijan Seal, Dipendra Nath Basu, Kripanjali Ghosh, Aryan Ramachandran, Rintu Kutum, Triveni Shelke, Ishaan Gupta, Imroze Khan

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Srijan Seal *Trivedi School of Biosciences, Ashoka University, Sonepat, Haryana 131029, India.ORCID 0000-0003-4610-3964
Dipendra Nath Basu *Trivedi School of Biosciences, Ashoka University, Sonepat, Haryana 131029, India.
Kripanjali GhoshTrivedi School of Biosciences, Ashoka University, Sonepat, Haryana 131029, India.
Aryan RamachandranTrivedi School of Biosciences, Ashoka University, Sonepat, Haryana 131029, India.
Rintu KutumTrivedi School of Biosciences, Ashoka University, Sonepat, Haryana 131029, India.ORCID 0000-0001-8667-6199
Triveni ShelkeDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
Ishaan GuptaDepartment of Biochemical Engineering and Biotechnology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
Imroze KhanTrivedi School of Biosciences, Ashoka University, Sonepat, Haryana 131029, India.ORCID 0000-0002-8793-5081

Funding

DST | Science and Engineering Research Board (SERB) ECR/2017/003370IITD-Ashoka MFRIP MI02416GWellcome TrustWellcome Trust DBT India Alliance (India Alliance) IA/I/20/1/504930
6 · The paper itself

Abstract

The occurrence of coinfections, where hosts are simultaneously infected by multiple pathogens, is widespread in nature and has significant negative impacts on global health. In humans, over one-sixth of the world's population is affected by coinfections, contributing to several diseases. However, despite the broad ecological relevance and impact on global health, most biomedical research has focused on understanding interactions between a single host and a single pathogen. The extent to which coinfections could impact host adaptation and immune system evolution, particularly in comparison to infections by single pathogens, thus remains largely unknown. Also, what roles do individual pathogen species play in this evolutionary process? To address these questions, in this study, we combined theoretical modeling and experimental validation in a model insect

Indexed as

Biological EvolutionCoinfectionHost-Pathogen InteractionsTriboliumAnimalsVirulenceadaptive dynamicscoinfecting pathogensexperimental evolutioninnate immunitytranscriptomics

Identifiers

PMID40267133
PMCPMC12054814

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.