Evidence map›Paper›PMID 40266885›Full record

ArticleJournal of the American Chemical Society2025

Catalyst-Controlled Regiodivergent Synthesis of Bicyclo[2.1.1]hexanes via Photochemical Strain-Release Cycloadditions.

Yu-Che Chang, María Martín, Kingsley Bortey, Quentin Lefebvre, Thomas Fessard, Christophe Salome, Ricardo Javier Vázquez, M Kevin Brown

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Umpolung Activation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu-Che ChangDepartment of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, Indiana 47405, United States.
María MartínDepartment of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, Indiana 47405, United States.ORCID 0000-0003-3453-2235
Kingsley BorteyDepartment of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, Indiana 47405, United States.
Quentin LefebvreSpiroChem AG, Rosental area, WRO-1047-3, Mattenstrasse 22, Basel, 4058, Switzerland.
Thomas FessardSpiroChem AG, Rosental area, WRO-1047-3, Mattenstrasse 22, Basel, 4058, Switzerland.
Christophe SalomeSpiroChem AG, Rosental area, WRO-1047-3, Mattenstrasse 22, Basel, 4058, Switzerland.ORCID 0000-0001-9668-8134
Ricardo Javier VázquezDepartment of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, Indiana 47405, United States.ORCID 0000-0003-3245-8123
M Kevin BrownDepartment of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, Indiana 47405, United States.ORCID 0000-0002-4993-0917

Funding

Methods and Strategies for Chemical SynthesisR35GM131755 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael Kevin Brown · 2019 to 2026
$4.0M
NIGMS NIH HHS R35 GM131755
6 · The paper itself

Abstract

Bicyclo[2.1.1]hexane is an emerging scaffold in various pharmaceutical settings, but the scarcity of approaches to target different regioisomers from a common starting material prevents targeting a broader range of chemical space. Herein, we demonstrate a new design for the photocatalyst-controlled regiodivergent synthesis of this scaffold. Of particular interest is that the synthesis of two distinct substitution patterns was achieved under photochemical conditions with catalyst control. This was possible due to the activating group,

Identifiers

PMID40266885
PMCPMC12854239

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.