Evidence map›Paper›PMID 40266880›Full record

ArticleeLife2025

Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2.

Joanna Kosinska, Julian C Assmann, Julica Inderhees, Helge Müller-Fielitz, Kristian Händler, Sven Geisler, Axel Künstner, Hauke Busch, Anna Worthmann, Joerg Heeren and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Joanna Kosinska *Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-3025-3685
Julian C Assmann *Institute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.
Julica InderheesInstitute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-4523-3652
Helge Müller-FielitzInstitute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-2815-4426
Kristian HändlerInstitute of Human Genetics, Universitätsklinikum Schleswig-Holstein, University of Lübeck and University of Kiel, Lübeck, Germany.
Sven GeislerCell Analysis Core Facility, University of Lübeck, Lübeck, Germany.
Axel KünstnerLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0003-0692-2105
Hauke BuschLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Anna WorthmannDepartment of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Joerg HeerenDepartment of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-5647-1034
Christian D SadikDepartment of Dermatology, Allergy, and Venereology, University of Lübeck, Lübeck, Germany.
Matthias GunzerInstitute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany.ORCID https://orcid.org/0000-0002-5534-6055
Vincent PrévotUniv. Lille, Inserm, CHU Lille, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, Lille, France.
Ruben NogueirasUniversidade de Santiago de Compostela-Instituto de Investigation Sanitaria, Santiago de Compostela, Spain.
Misa HiroseLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Malte SpielmannInstitute of Human Genetics, Universitätsklinikum Schleswig-Holstein, University of Lübeck and University of Kiel, Lübeck, Germany.ORCID https://orcid.org/0000-0002-0583-4683
Stefan OffermannsMax Planck Institute for Heart and Lung Research, Department of Pharmacology, Bad Nauheim, Germany.ORCID https://orcid.org/0000-0001-8676-6805
Nina WettschureckMax Planck Institute for Heart and Lung Research, Department of Pharmacology, Bad Nauheim, Germany.
Markus SchwaningerInstitute for Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism, University of Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-4510-9718

Funding

Bundesministerium für Bildung und Forschung Outlive-CRC-01KD2103ADeutsche Forschungsgemeinschaft SCHW 416/12-1Deutsche Forschungsgemeinschaft WE 2891/2-1European Research Council 10.3030/810331European Research Council 810331
6 · The paper itself

Abstract

Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF. We hypothesized that the variable response of patients may be due to their diet. In support of this hypothesis, mice subjected to experimental autoimmune encephalomyelitis (EAE), a model of MS, did not benefit from DMF treatment when fed a lauric acid (LA)-rich diet. Mice on normal chow (NC) diet, in contrast, and even more so mice on high-fiber (HFb) diet showed the expected protective DMF effect. DMF lacked efficacy in the LA diet-fed group despite similar resorption and preserved effects on plasma lipids. When mice were fed the permissive HFb diet, the protective effect of DMF treatment depended on hydroxycarboxylic receptor 2 (HCAR2), which is highly expressed in neutrophil granulocytes. Indeed, deletion of

Indexed as

DietDimethyl FumarateEncephalomyelitis, Autoimmune, ExperimentalImmunosuppressive AgentsMultiple SclerosisNeutrophilsReceptors, G-Protein-CoupledAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutDimethyl FumarateHcar2 protein, mouseImmunosuppressive AgentsReceptors, G-Protein-Coupledexperimental autoimmune encephalomyelitismedicinemousemultiple sclerosisneuroscienceneutrophils

Identifiers

PMID40266880
PMCPMC12113270

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.