Nanoscale Investigation of Elasticity Changes and Augmented Rigidity of Block Copolymer Micelles Induced by Reversible Core-Cross-Linking.

Xinyue Wang, Andreas Stihl, Christiane Höppener, Jürgen Vitz, Felix H Schacher, Volker Deckert

Abstract read

In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xinyue WangInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller University, D-07743 Jena, Germany.

Andreas StihlInstitute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller University, D-07743 Jena, Germany.

Christiane HöppenerInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller University, D-07743 Jena, Germany.

Jürgen VitzInstitute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller University, D-07743 Jena, Germany.

Felix H SchacherInstitute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller University, D-07743 Jena, Germany.ORCID 0000-0003-4685-6608

Volker DeckertInstitute of Physical Chemistry and Abbe Center of Photonics, Friedrich-Schiller University, D-07743 Jena, Germany.ORCID 0000-0002-0173-7974

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-delivery systems have attracted considerable attention due to their potential to increase the bioavailability of certain drugs and mitigate side effects by enabling targeted drug release. Reversibly core-cross-linked block copolymer micelles providing a hydrophilic and potentially nonimmunogenic shell and a hydrophobic core suitable for the uptake of hydrophobic drugs are frequently considered because of their high stability against environmental changes and dilution. Ultimately, triggering core-de-cross-linking enables the implementation of strategies for targeted drug release, which requests insights into the impact of varying nanomechanical properties on the stability of individual micelles. Here, atomic force microscopy nanoindentation in aqueous media is applied to intact α-allyl-PEG

Indexed as

Cross-Linking ReagentsMicellesPolymersElasticityHydrophobic and Hydrophilic InteractionsMicroscopy, Atomic ForcePolyethylene GlycolsCross-Linking ReagentsMicellesPolyethylene GlycolsPolymersatomic force microscopyblock copolymer micellesmechanical stabilitynanoindentationnanomechanical propertiesreversible cross-linking

Identifiers

PMID40266783

DOI10.1021/acsami.5c04826

PMCPMC12067378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.