Evidence map›Paper›PMID 40266741›Full record

ArticleInsects2025

Biochemical and Transcriptomic Analysis Reveals Low Temperature-Driven Oxidative Stress in Pupal

Xiangjie Zhu, Mingjie Cao, Chenyang Li, Chenyu Zhu, Han Li, Yuanmingyue Tian, Jiaqi Shang, Jiaqi Sun, Bingfeng Zhou, Xianda Wu and 2 more

Abstract read
In one paragraph

Article in Insects, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Tris[Antioxidants (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiangjie ZhuCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0002-5942-4161
Mingjie CaoCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0009-0006-8740-9846
Chenyang LiCenter for Plant Metabolomics, Haixia Institute of Science and Technology, College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0009-0000-8917-9585
Chenyu ZhuCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Han LiCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Yuanmingyue TianCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Jiaqi ShangCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Jiaqi SunCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Bingfeng ZhouCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Xianda WuAcademic Journal Department, Social Sciences Division, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
Shujing ZhouCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0003-4470-562X
Xinjian XuCollege of Bee Science and Biomedicine, Fujian Agriculture and Forestry University, Fuzhou 350002, China.ORCID 0000-0003-4101-1710

Funding

FAFU innovation funds for research KFA20064A, KFB23197 and KFB23101AFujian Natural Science Foundation Project 2021j01079Fujian provincial innovation funds for undergraduates S202310389087, S202110389080the Earmarked fund for China Agriculture Research System CARS-44-KXJ11
6 · The paper itself

Abstract

Exposure to low temperatures during honeybee development has been shown to impede brain development and affect cognitive function in adult bees. On the other hand, neuronal damage due to oxidative stress has been reported in many cases. Hence, biochemical parameters related to oxidative stress in honeybee pupae brain were determined. The levels of GSH in the pupal brain decreased after 24 h and 48 h of exposure to low temperatures; there were also reduced activities of SOD and CAT enzymes following 48 h of low-temperature treatment compared to the control group. Furthermore, analysis of transcriptome data post-24 h and -48 h low-temperature stress revealed the suppression of the glutathione metabolism and peroxisome pathways in pupal brains. Additionally, expression pattern clustering analysis and KEGG enrichment showed that 10 differentially expressed genes with down-regulated expression trends post-low-temperature treatment were significantly enriched in the peroxisome pathway, including

Indexed as

brain developmentcold stresshoneybeenewly pupated stageoxidative stress

Identifiers

PMID40266741
PMCPMC11942804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.