Evidence map›Paper›PMID 40266725›Full record

ArticleJournal of synchrotron radiation2025

Macromolecular crystallography and biology at the Linac Coherent Light Source.

Sandra Mous, Mark S Hunter, Frédéric Poitevin, Sébastien Boutet, Leland B Gee

Abstract read
In one paragraph

Article in Journal of synchrotron radiation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sandra MousLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0002-3532-5978
Mark S HunterLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
Frédéric PoitevinLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
Sébastien BoutetLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0003-3928-1244
Leland B GeeLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0002-5817-3997

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
High-end X-ray Detector System for Femtosecond CrystallographyS10OD023453 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2017 to 2017
$1.7M
High-Repetition Rate X-ray Detector for the Coherent X-ray Imaging Instrument at LCLSS10OD025079 · OD · STANFORD UNIVERSITY · PI BOUTET, SEBASTIEN · 2018 to 2018
$524k
National Institutes of Health, National Institute of General Medical Sciences P41GM103393NIGMS NIH HHS P41 GM103393NIH HHS S10 OD023453NIH HHS S10 OD025079US Department of Energy, Office of Science DE-AC02-76SF00515
6 · The paper itself

Abstract

The Linac Coherent Light Source (LCLS) has significantly impacted the field of biology by providing advanced capabilities for probing the structure and dynamics of biological molecules with high precision. The ultrashort coherent X-ray pulses from the LCLS have enabled ultrafast, time-resolved, serial femtosecond crystallography that is inaccessible at conventional synchrotron light sources. Since the facility's founding, scientists have captured detailed insights into biological processes at atomic resolution and fundamental timescales. The ability to observe these processes in real time and under conditions closely resembling their natural state is transforming our approach to studying biochemical mechanisms and developing new medical and energy applications. This work recounts some of the history of the LCLS, advances in biological research enabled by the LCLS, key biological areas that have been impacted and how the LCLS has helped to unravel complex biological phenomena in these fields.

Indexed as

Macromolecular SubstancesParticle AcceleratorsCrystallography, X-RaySynchrotronsMacromolecular Substancesprotein crystallographyroom-temperature crystallographyserial femtosecond crystallographytime-resolved crystallographyX-ray free-electron lasers

Identifiers

PMID40266725
PMCPMC12067347

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.